Kubodera NK - Search Results

1

Biological activities of 19-nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring.

Kubodera NK, Okano T, Nakagawa K, Ozono K, Mikami K. Kubodera NK, et al. Curr Pharm Des. 2000 May;6(7):791-801. doi: 10.2174/1381612003400452. Curr Pharm Des. 2000. PMID: 10828308

2

Synthetic studies of vitamin D analogs. XXIV. Synthesis of active vitamin D3 analogs substituted at the 2 beta-position and their preventive effects on bone mineral loss in ovariectomized rats.

Ono Y, Watanabe H, Shiraishi A, Takeda S, Higuchi Y, Sato K, Tsugawa N, Okano T, Kobayashi T, Kubodera N. Ono Y, et al. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1626-30. doi: 10.1248/cpb.45.1626. Chem Pharm Bull (Tokyo). 1997. PMID: 9353890

3

Singly dehydroxylated A-ring analogues of 19-nor-1alpha,25-dihydroxyvitamin D3 and 19-nor-22-oxa-1alpha,25-dihydroxyvitamin D3: novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor.

Okano T, Nakagawa K, Tsugawa N, Ozono K, Kubodera N, Osawa A, Terada M, Mikami K. Okano T, et al. Biol Pharm Bull. 1998 Dec;21(12):1300-5. doi: 10.1248/bpb.21.1300. Biol Pharm Bull. 1998. PMID: 9881643 Free article.

4

Rapid control of transmembrane calcium influx by 1alpha,25-dihydroxyvitamin D3 and its analogues in rat osteoblast-like cells.

Nakagawa K, Tsugawa N, Okamoto T, Kishi T, Ono T, Kubodera N, Okano T. Nakagawa K, et al. Biol Pharm Bull. 1999 Oct;22(10):1058-63. doi: 10.1248/bpb.22.1058. Biol Pharm Bull. 1999. PMID: 10549855 Free article.

5

In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D3.

Tsugawa N, Nakagawa K, Kurobe M, Ono Y, Kubodera N, Ozono K, Okano T. Tsugawa N, et al. Biol Pharm Bull. 2000 Jan;23(1):66-71. doi: 10.1248/bpb.23.66. Biol Pharm Bull. 2000. PMID: 10706413 Free article.

6

Catalytic asymmetric syntheses and biological activities of singly dehydroxylated 19-nor-1alpha,25-dihydroxyvitamin D(3) A-ring analogs in cancer cell differentiation and apoptosis.

Okano T, Nakagawa K, Kubodera N, Ozono K, Isaka A, Osawa A, Terada M, Mikami K. Okano T, et al. Chem Biol. 2000 Mar;7(3):173-84. doi: 10.1016/s1074-5521(00)00087-9. Chem Biol. 2000. PMID: 10712934

7

Synthesis and evaluation of A-ring diastereomers of 1alpha,25-dihydroxy-22-oxavitamin D3 (OCT).

Hatakeyama S, Okano T, Maeyama J, Esumi T, Hiyamizu H, Iwabuchi Y, Nakagawa K, Ozono K, Kawase A, Kubodera N. Hatakeyama S, et al. Bioorg Med Chem. 2001 Feb;9(2):403-15. doi: 10.1016/s0968-0896(00)00259-5. Bioorg Med Chem. 2001. PMID: 11249133

8

Asymmetric catalytic ene-cyclization approach to 2-fluoro-19-nor-1,25-dihydroxyvitamin D(3) A-ring analog with significant transactivation activity.

Mikami K, Ohba S, Ohmura H, Kubodera N, Nakagawa K, Okano T. Mikami K, et al. Chirality. 2001 Jul;13(7):366-71. doi: 10.1002/chir.1046. Chirality. 2001. PMID: 11400190

9

Two novel metabolic pathways of 22-oxacalcitriol (OCT). C-25 dehydration and C-3 epimerization and biological activities of novel OCT metabolites.

Kamao M, Tatematsu S, Hatakeyama S, Ozono K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. J Biol Chem. 2003 Jan 17;278(3):1463-71. doi: 10.1074/jbc.M203773200. Epub 2002 Nov 1. J Biol Chem. 2003. PMID: 12417596 Free article.

10

C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation.

Kamao M, Tatematsu S, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Ozono K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. J Biol Chem. 2004 Apr 16;279(16):15897-907. doi: 10.1074/jbc.M311473200. Epub 2004 Feb 2. J Biol Chem. 2004. PMID: 14757768 Free article.

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