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Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat.
Stemp G, Ashmeade T, Branch CL, Hadley MS, Hunter AJ, Johnson CN, Nash DJ, Thewlis KM, Vong AK, Austin NE, Jeffrey P, Avenell KY, Boyfield I, Hagan JJ, Middlemiss DN, Reavill C, Riley GJ, Routledge C, Wood M. Stemp G, et al. Among authors: hunter aj. J Med Chem. 2000 May 4;43(9):1878-85. doi: 10.1021/jm000090i. J Med Chem. 2000. PMID: 10794704
Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.
Reavill C, Taylor SG, Wood MD, Ashmeade T, Austin NE, Avenell KY, Boyfield I, Branch CL, Cilia J, Coldwell MC, Hadley MS, Hunter AJ, Jeffrey P, Jewitt F, Johnson CN, Jones DN, Medhurst AD, Middlemiss DN, Nash DJ, Riley GJ, Routledge C, Stemp G, Thewlis KM, Trail B, Vong AK, Hagan JJ. Reavill C, et al. Among authors: hunter aj. J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65. J Pharmacol Exp Ther. 2000. PMID: 10945872
Anxiolytic profile of ropinirole in the rat, mouse and common marmoset.
Rogers DC, Costall B, Domeney AM, Gerrard PA, Greener M, Kelly ME, Hagan JJ, Hunter AJ. Rogers DC, et al. Among authors: hunter aj. Psychopharmacology (Berl). 2000 Jul;151(1):91-7. doi: 10.1007/s002130000485. Psychopharmacology (Berl). 2000. PMID: 10958122
Development of SHIRPA to characterise the phenotype of gene-targeted mice.
Hatcher JP, Jones DN, Rogers DC, Hatcher PD, Reavill C, Hagan JJ, Hunter AJ. Hatcher JP, et al. Among authors: hunter aj. Behav Brain Res. 2001 Nov 1;125(1-2):43-7. doi: 10.1016/s0166-4328(01)00275-3. Behav Brain Res. 2001. PMID: 11682092 No abstract available.
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N. Hagan JJ, et al. Among authors: hunter aj. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6. doi: 10.1073/pnas.96.19.10911. Proc Natl Acad Sci U S A. 1999. PMID: 10485925 Free PMC article.
Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats.
Gartlon J, Szekeres P, Pullen M, Sarau HM, Aiyar N, Shabon U, Michalovich D, Steplewski K, Ellis C, Elshourbagy N, Duxon M, Ashmeade TE, Harrison DC, Murdock P, Wilson S, Ennaceur A, Atkins A, Heidbreder C, Hagan JJ, Hunter AJ, Jones DN. Gartlon J, et al. Among authors: hunter aj. Psychopharmacology (Berl). 2004 Dec;177(1-2):1-14. doi: 10.1007/s00213-004-1918-3. Epub 2004 Jun 16. Psychopharmacology (Berl). 2004. PMID: 15205870
186 results