Alessi DR - Search Results

1

Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase.

Deprez J, Bertrand L, Alessi DR, Krause U, Hue L, Rider MH. Deprez J, et al. Among authors: alessi dr. Biochem J. 2000 Apr 1;347 Pt 1(Pt 1):305-12. Biochem J. 2000. PMID: 10727432 Free PMC article.

2

Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades.

Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. Deprez J, et al. Among authors: alessi dr. J Biol Chem. 1997 Jul 11;272(28):17269-75. doi: 10.1074/jbc.272.28.17269. J Biol Chem. 1997. PMID: 9211863 Free article.

3

Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B.

Bertrand L, Alessi DR, Deprez J, Deak M, Viaene E, Rider MH, Hue L. Bertrand L, et al. Among authors: alessi dr. J Biol Chem. 1999 Oct 22;274(43):30927-33. doi: 10.1074/jbc.274.43.30927. J Biol Chem. 1999. PMID: 10521487 Free article.

4

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.

Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Sanchez Canedo C, et al. Among authors: alessi dr. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E761-9. doi: 10.1152/ajpendo.00421.2009. Epub 2010 Jan 5. Am J Physiol Endocrinol Metab. 2010. PMID: 20051528 Free article.

5

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.

Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, Mouton V, Kahn CR, Lucocq JM, Gray GA, Jovanović A, Alessi DR. Mora A, et al. Among authors: alessi dr. EMBO J. 2003 Sep 15;22(18):4666-76. doi: 10.1093/emboj/cdg469. EMBO J. 2003. PMID: 12970179 Free PMC article.

6

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Navé BT, et al. Among authors: alessi dr. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):427-31. Biochem J. 1999. PMID: 10567225 Free PMC article.

7

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Lizcano JM, Alrubaie S, Kieloch A, Deak M, Leevers SJ, Alessi DR. Lizcano JM, et al. Among authors: alessi dr. Biochem J. 2003 Sep 1;374(Pt 2):297-306. doi: 10.1042/BJ20030577. Biochem J. 2003. PMID: 12841848 Free PMC article.

8

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

Sakamoto K, Zarrinpashneh E, Budas GR, Pouleur AC, Dutta A, Prescott AR, Vanoverschelde JL, Ashworth A, Jovanović A, Alessi DR, Bertrand L. Sakamoto K, et al. Among authors: alessi dr. Am J Physiol Endocrinol Metab. 2006 May;290(5):E780-8. doi: 10.1152/ajpendo.00443.2005. Epub 2005 Dec 6. Am J Physiol Endocrinol Metab. 2006. PMID: 16332922 Free PMC article.

9

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.

Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. Cross DA, et al. Among authors: alessi dr. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):21-6. doi: 10.1042/bj3030021. Biochem J. 1994. PMID: 7945242 Free PMC article.

10

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.

Casamayor A, Morrice NA, Alessi DR. Casamayor A, et al. Among authors: alessi dr. Biochem J. 1999 Sep 1;342 ( Pt 2)(Pt 2):287-92. Biochem J. 1999. PMID: 10455013 Free PMC article.

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