Whittemore ER - Search Results

1

Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.

Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL. Guzikowski AP, et al. Among authors: whittemore er. J Med Chem. 2000 Mar 9;43(5):984-94. doi: 10.1021/jm990428c. J Med Chem. 2000. PMID: 10715162

2

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.

Zhou ZL, Kher SM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Among authors: whittemore er. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. doi: 10.1016/s0968-0896(03)00059-2. Bioorg Med Chem. 2003. PMID: 12659763

3

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: whittemore er. J Med Chem. 1996 Aug 16;39(17):3248-55. doi: 10.1021/jm960214k. J Med Chem. 1996. PMID: 8765507

4

Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist.

Ilyin VI, Whittemore ER, Tran M, Shen KZ, Cai SX, Kher SM, Keana JF, Weber E, Woodward RM. Ilyin VI, et al. Among authors: whittemore er. Eur J Pharmacol. 1996 Aug 29;310(2-3):107-14. doi: 10.1016/0014-2999(96)00370-6. Eur J Pharmacol. 1996. PMID: 8884205

5

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: whittemore er. J Med Chem. 1996 Nov 8;39(23):4682-6. doi: 10.1021/jm960520y. J Med Chem. 1996. PMID: 8917657

6

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. Hogenkamp DJ, et al. Among authors: whittemore er. J Med Chem. 1997 Jan 3;40(1):61-72. doi: 10.1021/jm960021x. J Med Chem. 1997. PMID: 9016329

7

Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.

Whittemore ER, Ilyin VI, Woodward RM. Whittemore ER, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):326-38. J Pharmacol Exp Ther. 1997. PMID: 9223571

8

Synthesis of racemic 6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones as antagonists of N-methyl-d-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

Guzikowski AP, Whittemore ER, Woodward RM, Weber E, Keana JF. Guzikowski AP, et al. Among authors: whittemore er. J Med Chem. 1997 Jul 18;40(15):2424-9. doi: 10.1021/jm960724e. J Med Chem. 1997. PMID: 9240357

9

Subtype-selective antagonism of NMDA receptors by nylidrin.

Whittemore ER, Ilyin VI, Konkoy CS, Woodward RM. Whittemore ER, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208. doi: 10.1016/s0014-2999(97)01292-2. Eur J Pharmacol. 1997. PMID: 9430414

10

Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.

Tamiz AP, Whittemore ER, Zhou ZL, Huang JC, Drewe JA, Chen JC, Cai SX, Weber E, Woodward RM, Keana JF. Tamiz AP, et al. Among authors: whittemore er. J Med Chem. 1998 Aug 27;41(18):3499-506. doi: 10.1021/jm980235+. J Med Chem. 1998. PMID: 9719603

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