Hawkinson JE - Search Results

1

Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.

Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL. Guzikowski AP, et al. Among authors: hawkinson je. J Med Chem. 2000 Mar 9;43(5):984-94. doi: 10.1021/jm990428c. J Med Chem. 2000. PMID: 10715162

2

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM. Hawkinson JE, et al. Mol Pharmacol. 1996 May;49(5):897-906. Mol Pharmacol. 1996. PMID: 8622640

3

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1996 Aug 16;39(17):3248-55. doi: 10.1021/jm960214k. J Med Chem. 1996. PMID: 8765507

4

Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.

Hawkinson JE, Acosta-Burruel M, Kimbrough CL, Goodnough DB, Wood PL. Hawkinson JE, et al. Eur J Pharmacol. 1996 May 23;304(1-3):141-6. doi: 10.1016/0014-2999(96)00090-8. Eur J Pharmacol. 1996. PMID: 8813596

5

The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase.

Hawkinson JE, Acosta-Burruel M, Wood PL. Hawkinson JE, et al. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. doi: 10.1016/0014-2999(96)00253-1. Eur J Pharmacol. 1996. PMID: 8832224

6

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

Guzikowski AP, Cai SX, Espitia SA, Hawkinson JE, Huettner JE, Nogales DF, Tran M, Woodward RM, Weber E, Keana JF. Guzikowski AP, et al. Among authors: hawkinson je. J Med Chem. 1996 Nov 8;39(23):4643-53. doi: 10.1021/jm960479z. J Med Chem. 1996. PMID: 8917653

7

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1996 Nov 8;39(23):4682-6. doi: 10.1021/jm960520y. J Med Chem. 1996. PMID: 8917657

8

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. Hogenkamp DJ, et al. Among authors: hawkinson je. J Med Chem. 1997 Jan 3;40(1):61-72. doi: 10.1021/jm960021x. J Med Chem. 1997. PMID: 9016329

9

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors.

Upasani RB, Yang KC, Acosta-Burruel M, Konkoy CS, McLellan JA, Woodward RM, Lan NC, Carter RB, Hawkinson JE. Upasani RB, et al. Among authors: hawkinson je. J Med Chem. 1997 Jan 3;40(1):73-84. doi: 10.1021/jm9605344. J Med Chem. 1997. PMID: 9016330

10

The N-methyl-D-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain.

Hawkinson JE, Huber KR, Sahota PS, Han Hsu H, Weber E, Whitehouse MJ. Hawkinson JE, et al. Brain Res. 1997 Jan 9;744(2):227-34. doi: 10.1016/S0006-8993(96)01064-5. Brain Res. 1997. PMID: 9027382

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