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Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage.
Kingma PS, Osheroff N. Kingma PS, et al. Among authors: osheroff n. J Biol Chem. 1997 Mar 14;272(11):7488-93. doi: 10.1074/jbc.272.11.7488. J Biol Chem. 1997. PMID: 9054451 Free article.
Apurinic sites are position-specific poisons of topoisomerase II and stimulate DNA scission approximately 10-18-fold when they are located within the 4-base overhang generated by enzyme-mediated cleavage (Kingma, P. S., and Osheroff, N. (1997) J. Biol. Chem. 272, 11 …
Apurinic sites are position-specific poisons of topoisomerase II and stimulate DNA scission approximately 10-18-fold when they are located w …
244 results