Hirschmann R - Search Results

1

Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.

Schiller PW, Berezowska I, Nguyen TM, Schmidt R, Lemieux C, Chung NN, Falcone-Hindley ML, Yao W, Liu J, Iwama S, Smith AB 3rd, Hirschmann R. Schiller PW, et al. Among authors: hirschmann r. J Med Chem. 2000 Feb 24;43(4):551-9. doi: 10.1021/jm990461z. J Med Chem. 2000. PMID: 10691681

2

Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.

Hirschmann R, Yao W, Cascieri MA, Strader CD, Maechler L, Cichy-Knight MA, Hynes J Jr, van Rijn RD, Sprengeler PA, Smith AB 3rd. Hirschmann R, et al. J Med Chem. 1996 Jun 21;39(13):2441-8. doi: 10.1021/jm960281e. J Med Chem. 1996. PMID: 8691440

3

Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.

Hirschmann R, Hynes J Jr, Cichy-Knight MA, van Rijn RD, Sprengeler PA, Spoors PG, Shakespeare WC, Pietranico-Cole S, Barbosa J, Liu J, Yao W, Rohrer S, Smith AB 3rd. Hirschmann R, et al. J Med Chem. 1998 Apr 23;41(9):1382-91. doi: 10.1021/jm9800346. J Med Chem. 1998. PMID: 9554871

4

Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.

Liu J, Underwood DJ, Cascieri MA, Rohrer SP, Cantin LD, Chicchi G, Smith AB 3rd, Hirschmann R. Liu J, et al. Among authors: hirschmann r. J Med Chem. 2000 Oct 19;43(21):3827-31. doi: 10.1021/jm000316h. J Med Chem. 2000. PMID: 11052787 No abstract available.

5

The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.

Smith AB 3rd, Knight SD, Sprengeler PA, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Bioorg Med Chem. 1996 Jul;4(7):1021-34. doi: 10.1016/0968-0896(96)00094-6. Bioorg Med Chem. 1996. PMID: 8831973 Free article.

6

Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.

Prasad V, Birzin ET, McVaugh CT, Van Rijn RD, Rohrer SP, Chicchi G, Underwood DJ, Thornton ER, Smith AB 3rd, Hirschmann R. Prasad V, et al. Among authors: hirschmann r. J Med Chem. 2003 May 8;46(10):1858-69. doi: 10.1021/jm0205088. J Med Chem. 2003. PMID: 12723949

7

Investigation of an antibody-ligase. Evidence for strain-induced catalysis.

Savinov SN, Hirschmann R, Benkovic SJ, Smith AB 3rd. Savinov SN, et al. Among authors: hirschmann r. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1321-4. doi: 10.1016/s0960-894x(03)00123-9. Bioorg Med Chem Lett. 2003. PMID: 12657273

8

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: hirschmann r. J Med Chem. 2003 May 8;46(10):1831-44. doi: 10.1021/jm0204587. J Med Chem. 2003. PMID: 12723947

9

Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.

Neelamkavil S, Arison B, Birzin E, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Thornton ER, Smith AB 3rd, Hirschmann R. Neelamkavil S, et al. Among authors: hirschmann r. J Med Chem. 2005 Jun 16;48(12):4025-30. doi: 10.1021/jm058184l. J Med Chem. 2005. PMID: 15943475

10

Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide formation and receptor affinity.

Lender A, Yao W, Sprengeler PA, Spanevello RA, Furst GT, Hirschmann R, Smith AB 3rd. Lender A, et al. Among authors: hirschmann r. Int J Pept Protein Res. 1993 Dec;42(6):509-17. doi: 10.1111/j.1399-3011.1993.tb00358.x. Int J Pept Protein Res. 1993. PMID: 8307682

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