St-Denis Y - Search Results

1

Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic (2S)-2-amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic acid at P1.

Narasimhan LS, Rubin JR, Holland DR, Plummer JS, Rapundalo ST, Edmunds JE, St-Denis Y, Siddiqui MA, Humblet C. Narasimhan LS, et al. J Med Chem. 2000 Feb 10;43(3):361-8. doi: 10.1021/jm990216f. J Med Chem. 2000. PMID: 10669563

2

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.

Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD. Plummer JS, et al. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3409-14. doi: 10.1016/s0960-894x(98)00613-1. Bioorg Med Chem Lett. 1998. PMID: 9873743

3

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.

Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Eaton S, Edmunds JJ, Holland DR, Lafleur D, Levesque S, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser A, St-Denis Y, Winocour P. Plummer JS, et al. Bioorg Med Chem Lett. 1999 Mar 22;9(6):835-40. doi: 10.1016/s0960-894x(99)00096-7. Bioorg Med Chem Lett. 1999. PMID: 10206546

4

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.

Cody WL, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, St-Denis Y, Winocour PD, Siddiqui MA. Cody WL, et al. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2497-502. doi: 10.1016/s0960-894x(99)00418-7. Bioorg Med Chem Lett. 1999. PMID: 10498196

5

Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.

St-Denis Y, Augelli-Szafran CE, Bachand B, Berryman KA, DiMaio J, Doherty AM, Edmunds JJ, Leblond L, Lévesque S, Narasimhan LS, Penvose-Yi JR, Rubin JR, Tarazi M, Winocour PD, Siddiqui MA. St-Denis Y, et al. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3193-8. doi: 10.1016/s0960-894x(98)00550-2. Bioorg Med Chem Lett. 1998. PMID: 9873701

6

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.

Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA. Bachand B, et al. Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. doi: 10.1016/s0960-894x(00)00636-3. Bioorg Med Chem Lett. 2001. PMID: 11212093

7

Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues.

Lévesque S, St-Denis Y, Bachand B, Préville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA. Lévesque S, et al. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. doi: 10.1016/s0960-894x(01)00661-8. Bioorg Med Chem Lett. 2001. PMID: 11720865

8

Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors.

St-Denis Y, Lévesque S, Bachand B, Edmunds JJ, Leblond L, Préville P, Tarazi M, Winocour PD, Siddiqui MA. St-Denis Y, et al. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1181-4. doi: 10.1016/s0960-894x(02)00131-2. Bioorg Med Chem Lett. 2002. PMID: 11934583

9

Synthesis and activity of 6-substituted purine linker amino acid immunostimulants.

Zacharie B, Gagnon L, Attardo G, Connolly TP, St-Denis Y, Penney CL. Zacharie B, et al. J Med Chem. 1997 Aug 29;40(18):2883-94. doi: 10.1021/jm960844m. J Med Chem. 1997. PMID: 9288170

10

Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.

Di Fabio R, St-Denis Y, Sabbatini FM, Andreotti D, Arban R, Bernasconi G, Braggio S, Blaney FE, Capelli AM, Castiglioni E, Di Modugno E, Donati D, Fazzolari E, Ratti E, Feriani A, Contini S, Gentile G, Ghirlanda D, Provera S, Marchioro C, Roberts KL, Mingardi A, Mattioli M, Nalin A, Pavone F, Spada S, Trist DG, Worby A. Di Fabio R, et al. Among authors: st denis y. J Med Chem. 2008 Dec 11;51(23):7370-9. doi: 10.1021/jm800744m. J Med Chem. 2008. PMID: 18989952

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