Foster PG - Search Results

1

The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.

Foster PG, Huang L, Santi DV, Stroud RM. Foster PG, et al. Nat Struct Biol. 2000 Jan;7(1):23-7. doi: 10.1038/71219. Nat Struct Biol. 2000. PMID: 10625422

2

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.

Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM. Finer-Moore J, et al. Among authors: foster pg. J Mol Biol. 1993 Aug 20;232(4):1101-16. doi: 10.1006/jmbi.1993.1463. J Mol Biol. 1993. PMID: 8371269

3

The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate.

Foster PG, Nunes CR, Greene P, Moustakas D, Stroud RM. Foster PG, et al. Structure. 2003 Dec;11(12):1609-20. doi: 10.1016/j.str.2003.10.014. Structure. 2003. PMID: 14656444 Free article.

4

Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate.

Eckstein JW, Foster PG, Finer-Moore J, Wataya Y, Santi DV. Eckstein JW, et al. Among authors: foster pg. Biochemistry. 1994 Dec 20;33(50):15086-94. doi: 10.1021/bi00254a018. Biochemistry. 1994. PMID: 7999767

5

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.

Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM. Tsai SC, et al. Among authors: foster pg. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14808-13. doi: 10.1073/pnas.011399198. Proc Natl Acad Sci U S A. 2001. PMID: 11752428 Free PMC article.

6

High-throughput structural biology in drug discovery: protein kinases.

Stout TJ, Foster PG, Matthews DJ. Stout TJ, et al. Among authors: foster pg. Curr Pharm Des. 2004;10(10):1069-82. doi: 10.2174/1381612043452695. Curr Pharm Des. 2004. PMID: 15078142 Review.

7

Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).

Takeuchi CS, Kim BG, Blazey CM, Ma S, Johnson HW, Anand NK, Arcalas A, Baik TG, Buhr CA, Cannoy J, Epshteyn S, Joshi A, Lara K, Lee MS, Wang L, Leahy JW, Nuss JM, Aay N, Aoyama R, Foster P, Lee J, Lehoux I, Munagala N, Plonowski A, Rajan S, Woolfrey J, Yamaguchi K, Lamb P, Miller N. Takeuchi CS, et al. J Med Chem. 2013 Mar 28;56(6):2218-34. doi: 10.1021/jm3007933. Epub 2013 Mar 7. J Med Chem. 2013. PMID: 23394126

8

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.

Leahy JW, Buhr CA, Johnson HW, Kim BG, Baik T, Cannoy J, Forsyth TP, Jeong JW, Lee MS, Ma S, Noson K, Wang L, Williams M, Nuss JM, Brooks E, Foster P, Goon L, Heald N, Holst C, Jaeger C, Lam S, Lougheed J, Nguyen L, Plonowski A, Song J, Stout T, Wu X, Yakes MF, Yu P, Zhang W, Lamb P, Raeber O. Leahy JW, et al. J Med Chem. 2012 Jun 14;55(11):5467-82. doi: 10.1021/jm300403a. Epub 2012 May 17. J Med Chem. 2012. PMID: 22548342

9

The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models.

Foster P, Yamaguchi K, Hsu PP, Qian F, Du X, Wu J, Won KA, Yu P, Jaeger CT, Zhang W, Marlowe CK, Keast P, Abulafia W, Chen J, Young J, Plonowski A, Yakes FM, Chu F, Engell K, Bentzien F, Lam ST, Dale S, Yturralde O, Matthews DJ, Lamb P, Laird AD. Foster P, et al. Mol Cancer Ther. 2015 Apr;14(4):931-40. doi: 10.1158/1535-7163.MCT-14-0833. Epub 2015 Jan 30. Mol Cancer Ther. 2015. PMID: 25637314

10

Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway.

Yu P, Laird AD, Du X, Wu J, Won KA, Yamaguchi K, Hsu PP, Qian F, Jaeger CT, Zhang W, Buhr CA, Shen P, Abulafia W, Chen J, Young J, Plonowski A, Yakes FM, Chu F, Lee M, Bentzien F, Lam ST, Dale S, Matthews DJ, Lamb P, Foster P. Yu P, et al. Mol Cancer Ther. 2014 May;13(5):1078-91. doi: 10.1158/1535-7163.MCT-13-0709. Epub 2014 Mar 14. Mol Cancer Ther. 2014. PMID: 24634413

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