Thorpe DS - Search Results

1

Efficient discovery of inhibitory ligands for diverse targets from a small combinatorial chemical library of chimeric molecules.

Thorpe DS, Edith Chan AW, Binnie A, Chen LC, Robinson A, Spoonamore J, Rodwell D, Wade S, Wilson S, Ackerman-Berrier M, Yeoman H, Walle S, Wu Q, Wertman KF. Thorpe DS, et al. Biochem Biophys Res Commun. 1999 Dec 9;266(1):62-5. doi: 10.1006/bbrc.1999.1775. Biochem Biophys Res Commun. 1999. PMID: 10581165

2

Combinatorial chemistry reveals a new motif that binds the platelet fibrinogen receptor, gpIIbIIIa.

Thorpe DS, Yeoman H, Chan AW, Krchnak V, Lebl M, Felder S. Thorpe DS, et al. Biochem Biophys Res Commun. 1999 Mar 24;256(3):537-41. doi: 10.1006/bbrc.1999.0374. Biochem Biophys Res Commun. 1999. PMID: 10080933

3

Combinatorial chemistry defines general properties of linkers for the optimal display of peptide ligands for binding soluble protein targets to TentaGel microscopic beads.

Thorpe DS, Walle S. Thorpe DS, et al. Biochem Biophys Res Commun. 2000 Mar 16;269(2):591-5. doi: 10.1006/bbrc.2000.2323. Biochem Biophys Res Commun. 2000. PMID: 10708599

4

On-bead and solution screening approaches for genomically derived targets. Discovery of surrogate ligands and substrates using combinatorial chemistry libraries.

Thorpe DS, Rossé G, Yeoman H, Wilson S, Willson P, Harlow G, Robinson A, Wertman KF. Thorpe DS, et al. Methods Mol Biol. 2002;201:239-63. doi: 10.1385/1-59259-285-6:239. Methods Mol Biol. 2002. PMID: 12357931 No abstract available.

5

Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry.

Ostrem JA, al-Obeidi F, Safar P, Safarova A, Stringer SK, Patek M, Cross MT, Spoonamore J, LoCascio JC, Kasireddy P, Thorpe DS, Sepetov N, Lebl M, Wildgoose P, Strop P. Ostrem JA, et al. Among authors: thorpe ds. Biochemistry. 1998 Jan 27;37(4):1053-9. doi: 10.1021/bi971147e. Biochemistry. 1998. PMID: 9454596

6

Forecasting roles of combinatorial chemistry in the age of genomically derived drug discovery targets.

Thorpe DS. Thorpe DS. Comb Chem High Throughput Screen. 2000 Oct;3(5):421-36. doi: 10.2174/1386207003331472. Comb Chem High Throughput Screen. 2000. PMID: 11032958 Review.

7

Forward & reverse chemical genetics using SPOS-based combinatorial chemistry.

Thorpe DS. Thorpe DS. Comb Chem High Throughput Screen. 2003 Nov;6(7):623-47. doi: 10.2174/138620703771981205. Comb Chem High Throughput Screen. 2003. PMID: 14683491 Review.

8

The guanylyl cyclase core of an atrial natriuretic peptide receptor: enzymatic properties and basis for cooperativity.

Thorpe DS, Niu S, Morkin E. Thorpe DS, et al. Biochem Biophys Res Commun. 1996 Jan 26;218(3):670-3. doi: 10.1006/bbrc.1996.0120. Biochem Biophys Res Commun. 1996. PMID: 8579572

9

Refolding parameters for the allosteric homodimeric guanylyl cyclase catalytic core from the atrial natriuretic peptide receptor.

Thorpe DS, Niu S, Morkin E. Thorpe DS, et al. Biochem Biophys Res Commun. 1996 Jul 25;224(3):765-71. doi: 10.1006/bbrc.1996.1097. Biochem Biophys Res Commun. 1996. PMID: 8713120

10

Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

Salmon SE, Lam KS, Lebl M, Kandola A, Khattri PS, Wade S, Pátek M, Kocis P, Krchnák V, Thorpe D, et al. Salmon SE, et al. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11708-12. doi: 10.1073/pnas.90.24.11708. Proc Natl Acad Sci U S A. 1993. PMID: 8265613 Free PMC article.

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