Brosch G - Search Results

1

Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.

Jung M, Brosch G, Kölle D, Scherf H, Gerhäuser C, Loidl P. Jung M, et al. Among authors: brosch g. J Med Chem. 1999 Nov 4;42(22):4669-79. doi: 10.1021/jm991091h. J Med Chem. 1999. PMID: 10579829

2

Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.

Wittich S, Scherf H, Xie C, Brosch G, Loidl P, Gerhäuser C, Jung M. Wittich S, et al. Among authors: brosch g. J Med Chem. 2002 Jul 18;45(15):3296-309. doi: 10.1021/jm0208119. J Med Chem. 2002. PMID: 12109913

3

A non-isotopic assay for histone deacetylase activity.

Hoffmann K, Brosch G, Loidl P, Jung M. Hoffmann K, et al. Among authors: brosch g. Nucleic Acids Res. 1999 May 1;27(9):2057-8. doi: 10.1093/nar/27.9.2057. Nucleic Acids Res. 1999. PMID: 10198441 Free PMC article.

4

First non-radioactive assay for in vitro screening of histone deacetylase inhibitors.

Hoffmann K, Brosch G, Loidl P, Jung M. Hoffmann K, et al. Among authors: brosch g. Pharmazie. 2000 Aug;55(8):601-6. Pharmazie. 2000. PMID: 10989838

5

3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.

Massa S, Mai A, Sbardella G, Esposito M, Ragno R, Loidl P, Brosch G. Massa S, et al. Among authors: brosch g. J Med Chem. 2001 Jun 21;44(13):2069-72. doi: 10.1021/jm015515v. J Med Chem. 2001. PMID: 11405644

6

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.

Mai A, Massa S, Ragno R, Esposito M, Sbardella G, Nocca G, Scatena R, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2002 Apr 25;45(9):1778-84. doi: 10.1021/jm011088+. J Med Chem. 2002. PMID: 11960489

7

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures.

Mai A, Massa S, Ragno R, Cerbara I, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2003 Feb 13;46(4):512-24. doi: 10.1021/jm021070e. J Med Chem. 2003. PMID: 12570373

8

Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.

Mai A, Massa S, Pezzi R, Rotili D, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2003 Nov 6;46(23):4826-9. doi: 10.1021/jm034167p. J Med Chem. 2003. PMID: 14584932

9

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Mai A, Massa S, Cerbara I, Valente S, Ragno R, Bottoni P, Scatena R, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2004 Feb 26;47(5):1098-109. doi: 10.1021/jm030990+. J Med Chem. 2004. PMID: 14971890

10

3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.

Ragno R, Mai A, Massa S, Cerbara I, Valente S, Bottoni P, Scatena R, Jesacher F, Loidl P, Brosch G. Ragno R, et al. Among authors: brosch g. J Med Chem. 2004 Mar 11;47(6):1351-9. doi: 10.1021/jm031036f. J Med Chem. 2004. PMID: 14998325

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