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Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: discovery of L-786,392.
Ratcliffe RW, Wilkening RR, Wildonger KJ, Waddell ST, Santorelli GM, Parker DL Jr, Morgan JD, Blizzard TA, Hammond ML, Heck JV, Huber J, Kohler J, Dorso KL, St Rose E, Sundelof JG, May WJ, Hammond GG. Ratcliffe RW, et al. Among authors: hammond gg. Bioorg Med Chem Lett. 1999 Mar 8;9(5):679-84. doi: 10.1016/s0960-894x(99)00071-2. Bioorg Med Chem Lett. 1999. PMID: 10201828
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
Rosen H, Hajdu R, Silver L, Kropp H, Dorso K, Kohler J, Sundelof JG, Huber J, Hammond GG, Jackson JJ, Gill CJ, Thompson R, Pelak BA, Epstein-Toney JH, Lankas G, Wilkening RR, Wildonger KJ, Blizzard TA, DiNinno FP, Ratcliffe RW, Heck JV, Kozarich JW, Hammond ML. Rosen H, et al. Among authors: hammond gg. Science. 1999 Jan 29;283(5402):703-6. doi: 10.1126/science.283.5402.703. Science. 1999. PMID: 9924033
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum beta-lactamase-and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates.
Kohler J, Dorso KL, Young K, Hammond GG, Rosen H, Kropp H, Silver LL. Kohler J, et al. Among authors: hammond gg. Antimicrob Agents Chemother. 1999 May;43(5):1170-6. doi: 10.1128/AAC.43.5.1170. Antimicrob Agents Chemother. 1999. PMID: 10223931 Free PMC article.
13 results