Pastan I - Search Results

1

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point.

Onda M, Kreitman RJ, Vasmatzis G, Lee B, Pastan I. Onda M, et al. Among authors: pastan i. J Immunol. 1999 Dec 1;163(11):6072-7. J Immunol. 1999. PMID: 10570296

2

Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.

Kreitman RJ, Schneider WP, Queen C, Tsudo M, Fitzgerald DJ, Waldmann TA, Pastan I. Kreitman RJ, et al. Among authors: pastan i. J Immunol. 1992 Oct 15;149(8):2810-5. J Immunol. 1992. PMID: 1401913

3

Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.

Kreitman RJ, Chaudhary VK, Kozak RW, FitzGerald DJ, Waldman TA, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Blood. 1992 Nov 1;80(9):2344-52. Blood. 1992. PMID: 1421405 Free article.

4

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.

Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8291-5. doi: 10.1073/pnas.87.21.8291. Proc Natl Acad Sci U S A. 1990. PMID: 2236041 Free PMC article.

5

Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.

Kreitman RJ, Puri RK, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Cancer Res. 1995 Aug 1;55(15):3357-63. Cancer Res. 1995. PMID: 7614471

6

Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor.

Kreitman RJ, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Biochem J. 1995 Apr 1;307 ( Pt 1)(Pt 1):29-37. doi: 10.1042/bj3070029. Biochem J. 1995. PMID: 7717988 Free PMC article.

7

Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog.

Webber KO, Reiter Y, Brinkmann U, Kreitman R, Pastan I. Webber KO, et al. Among authors: pastan i. Mol Immunol. 1995 Mar;32(4):249-58. doi: 10.1016/0161-5890(94)00150-y. Mol Immunol. 1995. PMID: 7723770

8

Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.

Kreitman RJ, Batra JK, Seetharam S, Chaudhary VK, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Bioconjug Chem. 1993 Mar-Apr;4(2):112-20. doi: 10.1021/bc00020a002. Bioconjug Chem. 1993. PMID: 7873642

9

Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.

Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I. Reiter Y, et al. Among authors: pastan i. Biochemistry. 1994 May 10;33(18):5451-9. doi: 10.1021/bi00184a014. Biochemistry. 1994. PMID: 7910034

We have recently described one example of a recombinant immunotoxin, B3(dsFv)-PE38KDEL, that is composed of such a dsFv connected to a truncated form of Pseudomonas exotoxin [Brinkmann, U., Reiter, Y., Jung, S.-H., Lee, B., & Pastan, I. (1993) Proc. Natl. Acad. …

We have recently described one example of a recombinant immunotoxin, B3(dsFv)-PE38KDEL, that is composed of such a dsFv connected to a trunc …

10

Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity.

Kreitman RJ, Puri RK, Leland P, Lee B, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Biochemistry. 1994 Sep 27;33(38):11637-44. doi: 10.1021/bi00204a027. Biochemistry. 1994. PMID: 7918378

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