Castro JL - Search Results

1

2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.

Russell MG, Beer MS, Stanton JA, Sohal B, Mortishire-Smith RJ, Castro JL. Russell MG, et al. Among authors: castro jl. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2491-6. doi: 10.1016/s0960-894x(99)00409-6. Bioorg Med Chem Lett. 1999. PMID: 10498195

2

Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, Wafford KA, Sheppard WF, Tye SJ. Jennings AS, et al. Among authors: castro jl. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1477-80. doi: 10.1016/j.bmcl.2005.12.044. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16386900

3

Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin- 2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor.

Castro JL, Baker R, Guiblin AR, Hobbs SC, Jenkins MR, Russell MG, Beer MS, Stanton JA, Scholey K, Hargreaves RJ, et al. Castro JL, et al. J Med Chem. 1994 Sep 16;37(19):3023-32. doi: 10.1021/jm00045a006. J Med Chem. 1994. PMID: 7932524

4

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.

Street LJ, Baker R, Castro JL, Chambers MS, Guiblin AR, Hobbs SC, Matassa VG, Reeve AJ, Beer MS, Middlemiss DN, et al. Street LJ, et al. Among authors: castro jl. J Med Chem. 1993 May 28;36(11):1529-38. doi: 10.1021/jm00063a003. J Med Chem. 1993. PMID: 8496922

5

3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.

Castro JL, Street LJ, Guiblin AR, Jelley RA, Russell MG, Sternfeld F, Beer MS, Stanton JA, Matassa VG. Castro JL, et al. J Med Chem. 1997 Oct 24;40(22):3497-500. doi: 10.1021/jm9704558. J Med Chem. 1997. PMID: 9357514 No abstract available.

6

Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.

Castro JL, Collins I, Russell MG, Watt AP, Sohal B, Rathbone D, Beer MS, Stanton JA. Castro JL, et al. J Med Chem. 1998 Jul 16;41(15):2667-70. doi: 10.1021/jm980204e. J Med Chem. 1998. PMID: 9667955 No abstract available.

7

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL. van Niel MB, et al. Among authors: castro jl. J Med Chem. 1999 Jun 17;42(12):2087-104. doi: 10.1021/jm981133m. J Med Chem. 1999. PMID: 10377215

8

Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.

van Niel MB, Beer MS, Castro JL, Cheng SK, Evans DC, Heald A, Hitzel L, Hunt P, Mortishire-Smith R, O'Connor D, Watt AP, MacLeod AM. van Niel MB, et al. Among authors: castro jl. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3243-8. doi: 10.1016/s0960-894x(99)00570-3. Bioorg Med Chem Lett. 1999. PMID: 10576696

9

3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.

Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL. Russell MG, et al. Among authors: castro jl. J Med Chem. 1999 Dec 2;42(24):4981-5001. doi: 10.1021/jm9910021. J Med Chem. 1999. PMID: 10585208

10

N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.

Russell MG, Baker RJ, Barden L, Beer MS, Bristow L, Broughton HB, Knowles M, McAllister G, Patel S, Castro JL. Russell MG, et al. Among authors: castro jl. J Med Chem. 2001 Nov 8;44(23):3881-95. doi: 10.1021/jm010943m. J Med Chem. 2001. PMID: 11689074

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