The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies.
Tsukahara T, Iwase N, Kawakami K, Iwasaki M, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Saga Y, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Ozawa K.
Tsukahara T, et al.
Gene Ther. 2015 Feb;22(2):209-15. doi: 10.1038/gt.2014.104. Epub 2014 Nov 27.
Gene Ther. 2015.
PMID: 25427612
Free PMC article.