Mendel DB - Search Results

1

Neuraminidase inhibitors as anti-influenza virus agents.

Kim CU, Chen X, Mendel DB. Kim CU, et al. Among authors: mendel db. Antivir Chem Chemother. 1999 Jul;10(4):141-54. doi: 10.1177/095632029901000401. Antivir Chem Chemother. 1999. PMID: 10480735 Free article. Review.

2

Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.

Mendel DB, Tai CY, Escarpe PA, Li W, Sidwell RW, Huffman JH, Sweet C, Jakeman KJ, Merson J, Lacy SA, Lew W, Williams MA, Zhang L, Chen MS, Bischofberger N, Kim CU. Mendel DB, et al. Antimicrob Agents Chemother. 1998 Mar;42(3):640-6. doi: 10.1128/AAC.42.3.640. Antimicrob Agents Chemother. 1998. PMID: 9517945 Free PMC article.

3

Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071.

Li W, Escarpe PA, Eisenberg EJ, Cundy KC, Sweet C, Jakeman KJ, Merson J, Lew W, Williams M, Zhang L, Kim CU, Bischofberger N, Chen MS, Mendel DB. Li W, et al. Among authors: mendel db. Antimicrob Agents Chemother. 1998 Mar;42(3):647-53. doi: 10.1128/AAC.42.3.647. Antimicrob Agents Chemother. 1998. PMID: 9517946 Free PMC article.

4

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

Kim CU, Lew W, Williams MA, Wu H, Zhang L, Chen X, Escarpe PA, Mendel DB, Laver WG, Stevens RC. Kim CU, et al. Among authors: mendel db. J Med Chem. 1998 Jul 2;41(14):2451-60. doi: 10.1021/jm980162u. J Med Chem. 1998. PMID: 9651151

5

Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.

Tai CY, Escarpe PA, Sidwell RW, Williams MA, Lew W, Wu H, Kim CU, Mendel DB. Tai CY, et al. Among authors: mendel db. Antimicrob Agents Chemother. 1998 Dec;42(12):3234-41. doi: 10.1128/AAC.42.12.3234. Antimicrob Agents Chemother. 1998. PMID: 9835519 Free PMC article.

6

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

Lew W, Wu H, Mendel DB, Escarpe PA, Chen X, Laver WG, Graves BJ, Kim CU. Lew W, et al. Among authors: mendel db. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3. Bioorg Med Chem Lett. 1998. PMID: 9873727

7

Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.

Zhang L, Williams MA, Mendel DB, Escarpe PA, Chen X, Wang KY, Graves BJ, Lawton G, Kim CU. Zhang L, et al. Among authors: mendel db. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1751-6. doi: 10.1016/s0960-894x(99)00280-2. Bioorg Med Chem Lett. 1999. PMID: 10406636

8

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

Lew W, Escarpe PA, Mendel DB, Sweeny DJ, Kim CU. Lew W, et al. Among authors: mendel db. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2811-4. doi: 10.1016/s0960-894x(99)00479-5. Bioorg Med Chem Lett. 1999. PMID: 10522696

9

Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.

Lew W, Wu H, Chen X, Graves BJ, Escarpe PA, MacArthur HL, Mendel DB, Kim CU. Lew W, et al. Among authors: mendel db. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1257-60. doi: 10.1016/s0960-894x(00)00214-6. Bioorg Med Chem Lett. 2000. PMID: 10866394

10

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

Kim CU, Lew W, Williams MA, Liu H, Zhang L, Swaminathan S, Bischofberger N, Chen MS, Mendel DB, Tai CY, Laver WG, Stevens RC. Kim CU, et al. Among authors: mendel db. J Am Chem Soc. 1997 Jan 29;119(4):681-90. doi: 10.1021/ja963036t. J Am Chem Soc. 1997. PMID: 16526129

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