Plé P - Search Results

1

A novel series of non-nucleoside inhibitors of inosine 5'-monophosphate dehydrogenase with immunosuppressive activity.

Franklin TJ, Morris WP, Jacobs VN, Culbert EJ, Heys CA, Ward WH, Cook PN, Jung F, Plé P. Franklin TJ, et al. Among authors: ple p. Biochem Pharmacol. 1999 Sep 1;58(5):867-76. doi: 10.1016/s0006-2952(99)00170-7. Biochem Pharmacol. 1999. PMID: 10449198

2

Glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid.

Franklin TJ, Jacobs V, Bruneau P, Ple P. Franklin TJ, et al. Among authors: ple p. Adv Enzyme Regul. 1995;35:91-100. doi: 10.1016/0065-2571(94)00010-z. Adv Enzyme Regul. 1995. PMID: 7572356

3

Human colorectal carcinoma cells in vitro as a means to assess the metabolism of analogs of mycophenolic acid.

Franklin TJ, Jacobs VN, Jones G, Ple P. Franklin TJ, et al. Among authors: ple p. Drug Metab Dispos. 1997 Mar;25(3):367-70. Drug Metab Dispos. 1997. PMID: 9172956

4

Glucuronidation associated with intrinsic resistance to mycophenolic acid in human colorectal carcinoma cells.

Franklin TJ, Jacobs V, Jones G, Plé P, Bruneau P. Franklin TJ, et al. Among authors: ple p. Cancer Res. 1996 Mar 1;56(5):984-7. Cancer Res. 1996. PMID: 8640790

5

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.

Green TP, Fennell M, Whittaker R, Curwen J, Jacobs V, Allen J, Logie A, Hargreaves J, Hickinson DM, Wilkinson RW, Elvin P, Boyer B, Carragher N, Plé PA, Bermingham A, Holdgate GA, Ward WH, Hennequin LF, Davies BR, Costello GF. Green TP, et al. Among authors: ple pa. Mol Oncol. 2009 Jun;3(3):248-61. doi: 10.1016/j.molonc.2009.01.002. Epub 2009 Feb 7. Mol Oncol. 2009. PMID: 19393585 Free PMC article.

6

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Thomas AP, Johnstone C, Stokes ES, Plé PA, Lohmann JJ, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO, Kendrew J, Lambert-van der Brempt C. Hennequin LF, et al. Among authors: ple pa. J Med Chem. 1999 Dec 30;42(26):5369-89. doi: 10.1021/jm990345w. J Med Chem. 1999. PMID: 10639280

7

Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

Barlaam B, Cosulich S, Degorce S, Fitzek M, Green S, Hancox U, Lambert-van der Brempt C, Lohmann JJ, Maudet M, Morgentin R, Péru A, Plé P, Saleh T, Ward L, Warin N. Barlaam B, et al. Among authors: ple p. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. doi: 10.1016/j.bmcl.2016.03.034. Epub 2016 Mar 11. Bioorg Med Chem Lett. 2016. PMID: 26996374

8

Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Lambert-van der Brempt C, Morgentin R, Pasquet G, Taylor S. Plé PA, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3050-5. doi: 10.1016/j.bmcl.2012.03.074. Epub 2012 Mar 28. Bioorg Med Chem Lett. 2012. PMID: 22497760

9

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S. Plé PA, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12. Bioorg Med Chem Lett. 2012. PMID: 22153662

10

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

Barlaam B, Cosulich S, Degorce S, Fitzek M, Giordanetto F, Green S, Inghardt T, Hennequin L, Hancox U, Lambert-van der Brempt C, Morgentin R, Pass S, Plé P, Saleh T, Ward L. Barlaam B, et al. Among authors: ple p. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3928-35. doi: 10.1016/j.bmcl.2014.06.040. Epub 2014 Jun 21. Bioorg Med Chem Lett. 2014. PMID: 24992874

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