Zhou ZL - Search Results

1

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109

2

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.

Zhou ZL, Kher SM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. doi: 10.1016/s0968-0896(03)00059-2. Bioorg Med Chem. 2003. PMID: 12659763

3

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: zhou zl. J Med Chem. 1996 Aug 16;39(17):3248-55. doi: 10.1021/jm960214k. J Med Chem. 1996. PMID: 8765507

4

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: zhou zl. J Med Chem. 1996 Nov 8;39(23):4682-6. doi: 10.1021/jm960520y. J Med Chem. 1996. PMID: 8917657

5

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: zhou zl. J Med Chem. 1997 Feb 28;40(5):730-8. doi: 10.1021/jm960654b. J Med Chem. 1997. PMID: 9057859

6

Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.

Tamiz AP, Whittemore ER, Zhou ZL, Huang JC, Drewe JA, Chen JC, Cai SX, Weber E, Woodward RM, Keana JF. Tamiz AP, et al. Among authors: zhou zl. J Med Chem. 1998 Aug 27;41(18):3499-506. doi: 10.1021/jm980235+. J Med Chem. 1998. PMID: 9719603

7

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.

Wright JL, Gregory TF, Bigge CF, Boxer PA, Serpa K, Meltzer LT, Wise LD, Cai SX, Hawkinson JE, Konkoy CS, Whittemore ER, Woodward RM, Zhou ZL. Wright JL, et al. Among authors: zhou zl. J Med Chem. 1999 Jul 1;42(13):2469-77. doi: 10.1021/jm990148x. J Med Chem. 1999. PMID: 10395488

8

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.

Tamiz AP, Cai SX, Zhou ZL, Yuen PW, Schelkun RM, Whittemore ER, Weber E, Woodward RM, Keana JF. Tamiz AP, et al. Among authors: zhou zl. J Med Chem. 1999 Aug 26;42(17):3412-20. doi: 10.1021/jm990199u. J Med Chem. 1999. PMID: 10464027

9

Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.

Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL. Guzikowski AP, et al. Among authors: zhou zl. J Med Chem. 2000 Mar 9;43(5):984-94. doi: 10.1021/jm990428c. J Med Chem. 2000. PMID: 10715162

10

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists.

Zhou ZL, Navratil JM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Bioorg Med Chem. 2001 Aug;9(8):2061-71. doi: 10.1016/s0968-0896(01)00115-8. Bioorg Med Chem. 2001. PMID: 11504642

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