Espitia SA - Search Results

1

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. Among authors: espitia sa. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109

2

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

Guzikowski AP, Cai SX, Espitia SA, Hawkinson JE, Huettner JE, Nogales DF, Tran M, Woodward RM, Weber E, Keana JF. Guzikowski AP, et al. Among authors: espitia sa. J Med Chem. 1996 Nov 8;39(23):4643-53. doi: 10.1021/jm960479z. J Med Chem. 1996. PMID: 8917653

3

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: espitia sa. J Med Chem. 1997 Feb 28;40(5):730-8. doi: 10.1021/jm960654b. J Med Chem. 1997. PMID: 9057859

4

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.

Cai SX, Huang JC, Espitia SA, Tran M, Ilyin VI, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: espitia sa. J Med Chem. 1997 Oct 24;40(22):3679-86. doi: 10.1021/jm970396y. J Med Chem. 1997. PMID: 9357535

5

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.

Wright JL, Gregory TF, Kesten SR, Boxer PA, Serpa KA, Meltzer LT, Wise LD, Espitia SA, Konkoy CS, Whittemore ER, Woodward RM. Wright JL, et al. Among authors: espitia sa. J Med Chem. 2000 Sep 7;43(18):3408-19. doi: 10.1021/jm000023o. J Med Chem. 2000. PMID: 10978188

6

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists.

Zhou ZL, Navratil JM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Among authors: espitia sa. Bioorg Med Chem. 2001 Aug;9(8):2061-71. doi: 10.1016/s0968-0896(01)00115-8. Bioorg Med Chem. 2001. PMID: 11504642

7

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.

Zhou ZL, Kher SM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Among authors: espitia sa. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. doi: 10.1016/s0968-0896(03)00059-2. Bioorg Med Chem. 2003. PMID: 12659763

8

Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding.

Hawkinson JE, Espitia SA. Hawkinson JE, et al. Among authors: espitia sa. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21. Eur J Pharmacol. 1997. PMID: 9226415

9

Opioid activity profiles indicate similarities between the nociceptin/orphanin FQ and opioid receptors.

Hawkinson JE, Acosta-Burruel M, Espitia SA. Hawkinson JE, et al. Among authors: espitia sa. Eur J Pharmacol. 2000 Feb 18;389(2-3):107-14. doi: 10.1016/s0014-2999(99)00904-8. Eur J Pharmacol. 2000. PMID: 10688973

10

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ. Smith BM, et al. Among authors: espitia s. J Med Chem. 2008 Jan 24;51(2):305-13. doi: 10.1021/jm0709034. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095642

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