Boxer PA - Search Results

1

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. Among authors: boxer pa. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109

2

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.

Wright JL, Gregory TF, Bigge CF, Boxer PA, Serpa K, Meltzer LT, Wise LD, Cai SX, Hawkinson JE, Konkoy CS, Whittemore ER, Woodward RM, Zhou ZL. Wright JL, et al. Among authors: boxer pa. J Med Chem. 1999 Jul 1;42(13):2469-77. doi: 10.1021/jm990148x. J Med Chem. 1999. PMID: 10395488

3

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.

Wright JL, Gregory TF, Kesten SR, Boxer PA, Serpa KA, Meltzer LT, Wise LD, Espitia SA, Konkoy CS, Whittemore ER, Woodward RM. Wright JL, et al. Among authors: boxer pa. J Med Chem. 2000 Sep 7;43(18):3408-19. doi: 10.1021/jm000023o. J Med Chem. 2000. PMID: 10978188

4

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.

Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. Among authors: boxer pa. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904

5

Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists.

Wright JL, Gregory TF, Boxer PA, Meltzer LT, Serpa KA, Wise LD. Wright JL, et al. Among authors: boxer pa. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2815-8. doi: 10.1016/s0960-894x(99)00482-5. Bioorg Med Chem Lett. 1999. PMID: 10522697

6

The neuroprotective effect of the novel AMPA receptor antagonist PD152247 (PNQX) in temporary focal ischemia in the rat.

Schielke GP, Kupina NC, Boxer PA, Bigge CF, Welty DF, Iadecola C. Schielke GP, et al. Among authors: boxer pa. Stroke. 1999 Jul;30(7):1472-7. doi: 10.1161/01.str.30.7.1472. Stroke. 1999. PMID: 10390325

7

A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.

Hajimohammadreza I, Probert AW, Coughenour LL, Borosky SA, Marcoux FW, Boxer PA, Wang KK. Hajimohammadreza I, et al. Among authors: boxer pa. J Neurosci. 1995 May;15(5 Pt 2):4093-101. doi: 10.1523/JNEUROSCI.15-05-04093.1995. J Neurosci. 1995. PMID: 7538570 Free PMC article.

8

Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.

Nikam SS, Cordon JJ, Ortwine DF, Heimbach TH, Blackburn AC, Vartanian MG, Nelson CB, Schwarz RD, Boxer PA, Rafferty MF. Nikam SS, et al. Among authors: boxer pa. J Med Chem. 1999 Jun 17;42(12):2266-71. doi: 10.1021/jm980455n. J Med Chem. 1999. PMID: 10377233

9

Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.

Boxer PA, Cordon JJ, Mann ME, Rodolosi LC, Vartanian MG, Rock DM, Taylor CP, Marcoux FW. Boxer PA, et al. Stroke. 1990 Nov;21(11 Suppl):III47-51. Stroke. 1990. PMID: 2237985

10

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

Hu LY, Boxer PA, Kesten SR, Lei HJ, Wustrow DJ, Moreland DW, Zhang L, Ahn K, Ryder TR, Liu X, Rubin JR, Fahnoe K, Carroll RT, Dutta S, Fahnoe DC, Probert AW, Roof RL, Rafferty MF, Kostlan CR, Scholten JD, Hood M, Ren XD, Schielke GP, Su TZ, Taylor CP, Mistry A, McConnell P, Hasemann C, Ohren J. Hu LY, et al. Among authors: boxer pa. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. doi: 10.1016/j.bmcl.2005.07.058. Epub 2005 Sep 6. Bioorg Med Chem Lett. 2006. PMID: 16143519

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