Walther M - Search Results

1

The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere.

Walther M, Holzhütter HG, Kuban RJ, Wiesner R, Rathmann J, Kühn H. Walther M, et al. Mol Pharmacol. 1999 Jul;56(1):196-203. doi: 10.1124/mol.56.1.196. Mol Pharmacol. 1999. PMID: 10385701

2

Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications.

Kuhn H, Walther M, Kuban RJ. Kuhn H, et al. Among authors: walther m. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:263-90. doi: 10.1016/s0090-6980(02)00035-7. Prostaglandins Other Lipid Mediat. 2002. PMID: 12432923 Review.

3

X-ray absorption studies into the iron ligand sphere of plant and animal lipoxygenases.

Kühn H, Kuban R, Walther M, Veldink GA. Kühn H, et al. Among authors: walther m. Adv Exp Med Biol. 1999;469:99-104. doi: 10.1007/978-1-4615-4793-8_15. Adv Exp Med Biol. 1999. PMID: 10667316 No abstract available.

4

Suicidal inactivation of the rabbit 15-lipoxygenase by 15S-HpETE is paralleled by covalent modification of active site peptides.

Wiesner R, Suzuki H, Walther M, Yamamoto S, Kuhn H. Wiesner R, et al. Among authors: walther m. Free Radic Biol Med. 2003 Feb 1;34(3):304-15. doi: 10.1016/s0891-5849(02)01244-3. Free Radic Biol Med. 2003. PMID: 12543246

5

Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium.

Walther M, Wiesner R, Kuhn H. Walther M, et al. J Biol Chem. 2004 Jan 30;279(5):3717-25. doi: 10.1074/jbc.M309564200. Epub 2003 Oct 31. J Biol Chem. 2004. PMID: 14594811 Free article.

6

Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.

Kuhn H, Saam J, Eibach S, Holzhütter HG, Ivanov I, Walther M. Kuhn H, et al. Among authors: walther m. Biochem Biophys Res Commun. 2005 Dec 9;338(1):93-101. doi: 10.1016/j.bbrc.2005.08.238. Epub 2005 Sep 9. Biochem Biophys Res Commun. 2005. PMID: 16168952 Review.

7

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.

Saam J, Ivanov I, Walther M, Holzhütter HG, Kuhn H. Saam J, et al. Among authors: walther m. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13319-24. doi: 10.1073/pnas.0702401104. Epub 2007 Aug 3. Proc Natl Acad Sci U S A. 2007. PMID: 17675410 Free PMC article.

8

The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions.

Walther M, Hofheinz K, Vogel R, Roffeis J, Kühn H. Walther M, et al. Arch Biochem Biophys. 2011 Dec 1;516(1):1-9. doi: 10.1016/j.abb.2011.09.004. Epub 2011 Sep 17. Arch Biochem Biophys. 2011. PMID: 21951814

9

Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.

Schwarz K, Walther M, Anton M, Gerth C, Feussner I, Kuhn H. Schwarz K, et al. Among authors: walther m. J Biol Chem. 2001 Jan 5;276(1):773-9. doi: 10.1074/jbc.M005114200. J Biol Chem. 2001. PMID: 11027682 Free article.

10

Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis.

Walther M, Ivanov I, Myagkova G, Kuhn H. Walther M, et al. Chem Biol. 2001 Aug;8(8):779-90. doi: 10.1016/s1074-5521(01)00050-3. Chem Biol. 2001. PMID: 11514227

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