Watt AP - Search Results

1

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL. van Niel MB, et al. Among authors: watt ap. J Med Chem. 1999 Jun 17;42(12):2087-104. doi: 10.1021/jm981133m. J Med Chem. 1999. PMID: 10377215

2

Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.

MacLeod AM, Street LJ, Reeve AJ, Jelley RA, Sternfeld F, Beer MS, Stanton JA, Watt AP, Rathbone D, Matassa VG. MacLeod AM, et al. Among authors: watt ap. J Med Chem. 1997 Oct 24;40(22):3501-3. doi: 10.1021/jm9704560. J Med Chem. 1997. PMID: 9357515 No abstract available.

3

Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.

Castro JL, Collins I, Russell MG, Watt AP, Sohal B, Rathbone D, Beer MS, Stanton JA. Castro JL, et al. Among authors: watt ap. J Med Chem. 1998 Jul 16;41(15):2667-70. doi: 10.1021/jm980204e. J Med Chem. 1998. PMID: 9667955 No abstract available.

4

Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.

Sternfeld F, Guiblin AR, Jelley RA, Matassa VG, Reeve AJ, Hunt PA, Beer MS, Heald A, Stanton JA, Sohal B, Watt AP, Street LJ. Sternfeld F, et al. Among authors: watt ap. J Med Chem. 1999 Feb 25;42(4):677-90. doi: 10.1021/jm9805687. J Med Chem. 1999. PMID: 10052975

5

3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.

Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM. Chambers MS, et al. Among authors: watt ap. J Med Chem. 1999 Feb 25;42(4):691-705. doi: 10.1021/jm980569z. J Med Chem. 1999. PMID: 10052976

6

Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.

van Niel MB, Beer MS, Castro JL, Cheng SK, Evans DC, Heald A, Hitzel L, Hunt P, Mortishire-Smith R, O'Connor D, Watt AP, MacLeod AM. van Niel MB, et al. Among authors: watt ap. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3243-8. doi: 10.1016/s0960-894x(99)00570-3. Bioorg Med Chem Lett. 1999. PMID: 10576696

7

3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.

Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL. Russell MG, et al. Among authors: watt ap. J Med Chem. 1999 Dec 2;42(24):4981-5001. doi: 10.1021/jm9910021. J Med Chem. 1999. PMID: 10585208

8

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

Cooper LC, Chicchi GG, Dinnell K, Elliott JM, Hollingworth GJ, Kurtz MM, Locker KL, Morrison D, Shaw DE, Tsao KL, Watt AP, Williams AR, Swain CJ. Cooper LC, et al. Among authors: watt ap. Bioorg Med Chem Lett. 2001 May 7;11(9):1233-6. doi: 10.1016/s0960-894x(01)00182-2. Bioorg Med Chem Lett. 2001. PMID: 11354384

9

Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.

Street LJ, Baker R, Davey WB, Guiblin AR, Jelley RA, Reeve AJ, Routledge H, Sternfeld F, Watt AP, Beer MS, et al. Street LJ, et al. Among authors: watt ap. J Med Chem. 1995 May 12;38(10):1799-810. doi: 10.1021/jm00010a025. J Med Chem. 1995. PMID: 7752204

10

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R, Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG. Castro JL, et al. Among authors: watt ap. J Med Chem. 1996 Feb 16;39(4):842-9. doi: 10.1021/jm9506736. J Med Chem. 1996. PMID: 8632408

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