Locker KL - Search Results

1

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL. van Niel MB, et al. Among authors: locker kl. J Med Chem. 1999 Jun 17;42(12):2087-104. doi: 10.1021/jm981133m. J Med Chem. 1999. PMID: 10377215

2

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

Cooper LC, Chicchi GG, Dinnell K, Elliott JM, Hollingworth GJ, Kurtz MM, Locker KL, Morrison D, Shaw DE, Tsao KL, Watt AP, Williams AR, Swain CJ. Cooper LC, et al. Among authors: locker kl. Bioorg Med Chem Lett. 2001 May 7;11(9):1233-6. doi: 10.1016/s0960-894x(01)00182-2. Bioorg Med Chem Lett. 2001. PMID: 11354384

3

Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS.

Watt AP, Morrison D, Locker KL, Evans DC. Watt AP, et al. Among authors: locker kl. Anal Chem. 2000 Mar 1;72(5):979-84. doi: 10.1021/ac9906633. Anal Chem. 2000. PMID: 10739201

4

Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry.

Locker KL, Morrison D, Watt AP. Locker KL, et al. J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):13-23. doi: 10.1016/s0378-4347(00)00369-8. J Chromatogr B Biomed Sci Appl. 2001. PMID: 11204213

5

Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists.

Watt AP, Hitzel L, Morrison D, Locker KL. Watt AP, et al. Among authors: locker kl. J Chromatogr A. 2000 Oct 27;896(1-2):217-27. doi: 10.1016/s0021-9673(00)00575-6. J Chromatogr A. 2000. PMID: 11093657

6

Determination of the in vitro metabolism of (+)- and (-)-epibatidine.

Watt AP, Hitzel L, Morrison D, Locker KL. Watt AP, et al. Among authors: locker kl. J Chromatogr A. 2000 Oct 27;896(1-2):229-38. doi: 10.1016/s0021-9673(00)00597-5. J Chromatogr A. 2000. PMID: 11093658

7

An increased throughput method for the determination of partition coefficients.

Hitzel L, Watt AP, Locker KL. Hitzel L, et al. Among authors: locker kl. Pharm Res. 2000 Nov;17(11):1389-95. doi: 10.1023/a:1007546905874. Pharm Res. 2000. PMID: 11205732

8

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Hop CE, et al. Drug Metab Dispos. 2002 Aug;30(8):937-43. doi: 10.1124/dmd.30.8.937. Drug Metab Dispos. 2002. PMID: 12124313

9

Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.

Conley RK, Cumberbatch MJ, Mason GS, Williamson DJ, Harrison T, Locker K, Swain C, Maubach K, O'Donnell R, Rigby M, Hewson L, Smith D, Rupniak NM. Conley RK, et al. J Neurosci. 2002 Sep 1;22(17):7730-6. doi: 10.1523/JNEUROSCI.22-17-07730.2002. J Neurosci. 2002. PMID: 12196596 Free PMC article.

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