Segall Y - Search Results

1

Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL. Millard CB, et al. Among authors: segall y. Biochemistry. 1999 Jun 1;38(22):7032-9. doi: 10.1021/bi982678l. Biochemistry. 1999. PMID: 10353814

2

Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.

Ordentlich A, Barak D, Kronman C, Benschop HP, De Jong LP, Ariel N, Barak R, Segall Y, Velan B, Shafferman A. Ordentlich A, et al. Among authors: segall y. Biochemistry. 1999 Mar 9;38(10):3055-66. doi: 10.1021/bi982261f. Biochemistry. 1999. PMID: 10074358

3

Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.

Barak D, Ordentlich A, Kaplan D, Barak R, Mizrahi D, Kronman C, Segall Y, Velan B, Shafferman A. Barak D, et al. Among authors: segall y. Biochemistry. 2000 Feb 8;39(5):1156-61. doi: 10.1021/bi992009n. Biochemistry. 2000. PMID: 10653663

4

Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.

Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A. Ordentlich A, et al. Among authors: segall y. Biochemistry. 2004 Sep 7;43(35):11255-65. doi: 10.1021/bi0490946. Biochemistry. 2004. PMID: 15366935

5

Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.

Steinberg N, van der Drift AC, Grunwald J, Segall Y, Shirin E, Haas E, Ashani Y, Silman I. Steinberg N, et al. Among authors: segall y. Biochemistry. 1989 Feb 7;28(3):1248-53. doi: 10.1021/bi00429a044. Biochemistry. 1989. PMID: 2713362

6

Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.

Segall Y, Waysbort D, Barak D, Ariel N, Doctor BP, Grunwald J, Ashani Y. Segall Y, et al. Biochemistry. 1993 Dec 14;32(49):13441-50. doi: 10.1021/bi00212a009. Biochemistry. 1993. PMID: 8257680

7

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.

Ordentlich A, Barak D, Kronman C, Flashner Y, Leitner M, Segall Y, Ariel N, Cohen S, Velan B, Shafferman A. Ordentlich A, et al. Among authors: segall y. J Biol Chem. 1993 Aug 15;268(23):17083-95. J Biol Chem. 1993. PMID: 8349597 Free article.

8

The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.

Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A. Ordentlich A, et al. Among authors: segall y. J Biol Chem. 1996 May 17;271(20):11953-62. doi: 10.1074/jbc.271.20.11953. J Biol Chem. 1996. PMID: 8662593 Free article.

9

Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry.

Barak R, Ordentlich A, Barak D, Fischer M, Benschop HP, De Jong LP, Segall Y, Velan B, Shafferman A. Barak R, et al. Among authors: segall y. FEBS Lett. 1997 May 5;407(3):347-52. doi: 10.1016/s0014-5793(97)00375-x. FEBS Lett. 1997. PMID: 9175882 Free article.

10

Functional characteristics of the oxyanion hole in human acetylcholinesterase.

Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A. Ordentlich A, et al. Among authors: segall y. J Biol Chem. 1998 Jul 31;273(31):19509-17. doi: 10.1074/jbc.273.31.19509. J Biol Chem. 1998. PMID: 9677373 Free article.

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