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Page 1
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard JC, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D'Amore PA, Shima DT. Carmeliet P, et al. Among authors: brusselmans k. Nat Med. 1999 May;5(5):495-502. doi: 10.1038/8379. Nat Med. 1999. PMID: 10229225 No abstract available.
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P. Compernolle V, et al. Among authors: brusselmans k. Nat Med. 2002 Jul;8(7):702-10. doi: 10.1038/nm721. Epub 2002 Jun 10. Nat Med. 2002. PMID: 12053176
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.
Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P. Oosthuyse B, et al. Among authors: brusselmans k. Nat Genet. 2001 Jun;28(2):131-8. doi: 10.1038/88842. Nat Genet. 2001. PMID: 11381259
Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia.
Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, Collen D, Herbert JM, Carmeliet P. Brusselmans K, et al. J Biol Chem. 2001 Oct 19;276(42):39192-6. doi: 10.1074/jbc.C100428200. Epub 2001 Aug 23. J Biol Chem. 2001. PMID: 11546756 Free article.
Neurosci. 19, 6818-6824 and Carmeliet, P., Dor, Y., Herbert, J. M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., Koch, C. J., Ratcliffe, P., Moons, L., Jain, R. K., Collen, D., and Keshet, E. (1998) Nature …
Neurosci. 19, 6818-6824 and Carmeliet, P., Dor, Y., Herbert, J. M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., …
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P. Acker T, et al. Among authors: brusselmans k. Cancer Cell. 2005 Aug;8(2):131-41. doi: 10.1016/j.ccr.2005.07.003. Cancer Cell. 2005. PMID: 16098466 Free article.
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