Melnick RL - Search Results

1

High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.

Sills RC, Hong HL, Melnick RL, Boorman GA, Devereux TR. Sills RC, et al. Among authors: melnick rl. Carcinogenesis. 1999 Apr;20(4):657-62. doi: 10.1093/carcin/20.4.657. Carcinogenesis. 1999. PMID: 10223196

2

Inhalation toxicity and carcinogenicity of isoprene in rats and mice: comparisons with 1,3-butadiene.

Melnick RL, Sills RC, Roycroft JH, Chou BJ, Ragan HA, Miller RA. Melnick RL, et al. Toxicology. 1996 Oct 28;113(1-3):247-52. doi: 10.1016/0300-483x(96)03453-1. Toxicology. 1996. PMID: 8901905 Review.

3

Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.

Hong HL, Devereux TR, Melnick RL, Eldridge SR, Greenwell A, Haseman J, Boorman GA, Sills RC. Hong HL, et al. Among authors: melnick rl. Carcinogenesis. 1997 Apr;18(4):783-9. doi: 10.1093/carcin/18.4.783. Carcinogenesis. 1997. PMID: 9111215

4

Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice.

Melnick RL, Sills RC, Portier CJ, Roycroft JH, Chou BJ, Grumbein SL, Miller RA. Melnick RL, et al. Carcinogenesis. 1999 May;20(5):867-78. doi: 10.1093/carcin/20.5.867. Carcinogenesis. 1999. PMID: 10334205

5

Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.

Hong HH, Devereux TR, Melnick RL, Moomaw CR, Boorman GA, Sills RC. Hong HH, et al. Among authors: melnick rl. Toxicol Pathol. 2000 Jul-Aug;28(4):529-34. doi: 10.1177/019262330002800404. Toxicol Pathol. 2000. PMID: 10930038

6

Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice.

Melnick RL, Sills RC. Melnick RL, et al. Chem Biol Interact. 2001 Jun 1;135-136:27-42. doi: 10.1016/s0009-2797(01)00213-7. Chem Biol Interact. 2001. PMID: 11397379 Review.

7

Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.

Sills RC, Hong HL, Boorman GA, Devereux TR, Melnick RL. Sills RC, et al. Among authors: melnick rl. Chem Biol Interact. 2001 Jun 1;135-136:373-86. doi: 10.1016/s0009-2797(01)00179-x. Chem Biol Interact. 2001. PMID: 11397402

8

Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure.

Melnick RL, Sills RC, Roycroft JH, Chou BJ, Ragan HA, Miller RA. Melnick RL, et al. Cancer Res. 1994 Oct 15;54(20):5333-9. Cancer Res. 1994. PMID: 7923161

9

Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.

Kim Y, Hong HH, Lachat Y, Clayton NP, Devereux TR, Melnick RL, Hegi ME, Sills RC. Kim Y, et al. Among authors: melnick rl. Toxicol Pathol. 2005;33(3):307-12. doi: 10.1080/01926230590922848. Toxicol Pathol. 2005. PMID: 15814359

10

Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.

Ton TV, Hong HH, Devereux TR, Melnick RL, Sills RC, Kim Y. Ton TV, et al. Among authors: melnick rl. Chem Biol Interact. 2007 Mar 20;166(1-3):112-20. doi: 10.1016/j.cbi.2006.04.015. Epub 2006 May 2. Chem Biol Interact. 2007. PMID: 16860786

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