Sparks A - Search Results

1

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs.

Laín S, Midgley C, Sparks A, Lane EB, Lane DP. Laín S, et al. Among authors: sparks a. Exp Cell Res. 1999 May 1;248(2):457-72. doi: 10.1006/excr.1999.4433. Exp Cell Res. 1999. PMID: 10222137

2

Small peptides activate the latent sequence-specific DNA binding function of p53.

Hupp TR, Sparks A, Lane DP. Hupp TR, et al. Among authors: sparks a. Cell. 1995 Oct 20;83(2):237-45. doi: 10.1016/0092-8674(95)90165-5. Cell. 1995. PMID: 7585941 Free article.

3

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP. Saville MK, et al. Among authors: sparks a. J Biol Chem. 2004 Oct 1;279(40):42169-81. doi: 10.1074/jbc.M403362200. Epub 2004 Jul 26. J Biol Chem. 2004. PMID: 15280377 Free article.

4

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

Picksley SM, Vojtesek B, Sparks A, Lane DP. Picksley SM, et al. Among authors: sparks a. Oncogene. 1994 Sep;9(9):2523-9. Oncogene. 1994. PMID: 8058315

5

Epitope analysis of the murine p53 tumour suppressor protein.

Lane DP, Stephen CW, Midgley CA, Sparks A, Hupp TR, Daniels DA, Greaves R, Reid A, Vojtesek B, Picksley SM. Lane DP, et al. Among authors: sparks a. Oncogene. 1996 Jun 6;12(11):2461-6. Oncogene. 1996. PMID: 8649788

6

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

Böttger A, Böttger V, Sparks A, Liu WL, Howard SF, Lane DP. Böttger A, et al. Among authors: sparks a. Curr Biol. 1997 Nov 1;7(11):860-9. doi: 10.1016/s0960-9822(06)00374-5. Curr Biol. 1997. PMID: 9382809 Free article.

7

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53.

Blattner C, Sparks A, Lane D. Blattner C, et al. Among authors: sparks a. Mol Cell Biol. 1999 May;19(5):3704-13. doi: 10.1128/MCB.19.5.3704. Mol Cell Biol. 1999. PMID: 10207094 Free PMC article.

8

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo.

Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT, Lane DP. Midgley CA, et al. Among authors: sparks a. Oncogene. 2000 May 4;19(19):2312-23. doi: 10.1038/sj.onc.1203593. Oncogene. 2000. PMID: 10822382

9

MdmX is a substrate for the deubiquitinating enzyme USP2a.

Allende-Vega N, Sparks A, Lane DP, Saville MK. Allende-Vega N, et al. Among authors: sparks a. Oncogene. 2010 Jan 21;29(3):432-41. doi: 10.1038/onc.2009.330. Epub 2009 Oct 19. Oncogene. 2010. PMID: 19838211

10

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.

Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. Stevenson LF, et al. Among authors: sparks a. EMBO J. 2007 Feb 21;26(4):976-86. doi: 10.1038/sj.emboj.7601567. Epub 2007 Feb 8. EMBO J. 2007. PMID: 17290220 Free PMC article.

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