Goldfarb PS - Search Results

1

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Ogg MS, Williams JM, Tarbit M, Goldfarb PS, Gray TJ, Gibson GG. Ogg MS, et al. Among authors: goldfarb ps. Xenobiotica. 1999 Mar;29(3):269-79. doi: 10.1080/004982599238669. Xenobiotica. 1999. PMID: 10219967

2

Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5'-flanking region.

Hamzeiy H, Bombail V, Plant N, Gibson G, Goldfarb P. Hamzeiy H, et al. Xenobiotica. 2003 Nov;33(11):1085-95. doi: 10.1080/00498250310001609165. Xenobiotica. 2003. PMID: 14660173

3

Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene.

Richardson TH, Schenkman JB, Turcan R, Goldfarb PS, Gibson GG. Richardson TH, et al. Among authors: goldfarb ps. Xenobiotica. 1992 Jun;22(6):621-31. doi: 10.3109/00498259209053125. Xenobiotica. 1992. PMID: 1441586

4

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.

Lewis DF, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1997 Apr;27(4):319-39. doi: 10.1080/004982597240497. Xenobiotica. 1997. PMID: 9149373

5

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.

Lewis DF, Dickins M, Weaver RJ, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1998 Mar;28(3):235-68. doi: 10.1080/004982598239542. Xenobiotica. 1998. PMID: 9574814

6

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.

Lewis DF, Lake BG, Dickins M, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1999 Apr;29(4):361-93. doi: 10.1080/004982599238560. Xenobiotica. 1999. PMID: 10375007

7

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform.

Lewis DF, Bird MG, Dickins M, Lake BG, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 2000 Jan;30(1):1-25. doi: 10.1080/004982500237794. Xenobiotica. 2000. PMID: 10659948

8

Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor alpha (hERalpha) LBD: quantitative structure-activity relationships within a series of CYP3A4 inducers where induction is mediated via hGR involvement.

Lewis DF, Ogg MS, Goldfarb PS, Gibson GG. Lewis DF, et al. Among authors: goldfarb ps. J Steroid Biochem Mol Biol. 2002 Oct;82(2-3):195-9. doi: 10.1016/s0960-0760(02)00158-9. J Steroid Biochem Mol Biol. 2002. PMID: 12477485

9

Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals.

Lewis DF, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1996 Oct;26(10):1067-86. doi: 10.3109/00498259609167423. Xenobiotica. 1996. PMID: 8905920

10

Influence of single and concurrent clofibrate and phenobarbital administration on cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation in male rat liver.

Close I, Shackleton G, Goldfarb PS, Gibson GG, Sharma R, Howes D. Close I, et al. Among authors: goldfarb ps. J Biochem Toxicol. 1992 Fall;7(3):193-8. doi: 10.1002/jbt.2570070309. J Biochem Toxicol. 1992. PMID: 1479597

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