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Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).
Discafani CM, Carroll ML, Floyd MB Jr, Hollander IJ, Husain Z, Johnson BD, Kitchen D, May MK, Malo MS, Minnick AA Jr, Nilakantan R, Shen R, Wang YF, Wissner A, Greenberger LM. Discafani CM, et al. Among authors: malo ms. Biochem Pharmacol. 1999 Apr 15;57(8):917-25. doi: 10.1016/s0006-2952(98)00356-6. Biochem Pharmacol. 1999. PMID: 10086326
Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.
Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, Chen KT, Moss AK, Ramasamy S, Faruqui A, Hodin S, Malo PS, Ebrahimi F, Biswas B, Narisawa S, Millán JL, Warren HS, Kaplan JB, Kitts CL, Hohmann EL, Hodin RA. Malo MS, et al. Among authors: malo ps. Gut. 2010 Nov;59(11):1476-84. doi: 10.1136/gut.2010.211706. Gut. 2010. PMID: 20947883
The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.
Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. Shin J, et al. Among authors: malo ms. J Biol Chem. 2014 Sep 5;289(36):25306-16. doi: 10.1074/jbc.M114.557546. Epub 2014 Jul 18. J Biol Chem. 2014. PMID: 25037223 Free PMC article.
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.
Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. Chen KT, et al. Among authors: malo ms. Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G467-75. doi: 10.1152/ajpgi.00364.2009. Epub 2010 May 20. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20489044 Free PMC article.
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis.
Ramasamy S, Nguyen DD, Eston MA, Alam SN, Moss AK, Ebrahimi F, Biswas B, Mostafa G, Chen KT, Kaliannan K, Yammine H, Narisawa S, Millán JL, Warren HS, Hohmann EL, Mizoguchi E, Reinecker HC, Bhan AK, Snapper SB, Malo MS, Hodin RA. Ramasamy S, et al. Among authors: malo ms. Inflamm Bowel Dis. 2011 Feb;17(2):532-42. doi: 10.1002/ibd.21377. Inflamm Bowel Dis. 2011. PMID: 20645323 Free PMC article.
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.
Chen KT, Malo MS, Beasley-Topliffe LK, Poelstra K, Millan JL, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. Chen KT, et al. Among authors: malo ms. Dig Dis Sci. 2011 Apr;56(4):1020-7. doi: 10.1007/s10620-010-1396-x. Epub 2010 Sep 16. Dig Dis Sci. 2011. PMID: 20844955 Free PMC article.
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