Doxycycline control of prion protein transgene expression modulates prion disease in mice.
Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB.
Tremblay P, et al. Among authors: bujard h.
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12580-5. doi: 10.1073/pnas.95.21.12580.
Proc Natl Acad Sci U S A. 1998.
PMID: 9770528
Free PMC article.
To control the expression of PrPC in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by the PrP gene control elements and a tTA-responsive promoter linked to a PrP gene [Gossen, M. and Bujard, H. (1992) Proc. Natl. Acad. Sci. USA …
To control the expression of PrPC in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by the PrP gene con …