Is an intravenous bolus injection required prior to initiating slow intravenous infusion of PACAP38 for prevention of neuronal death induced by global ischemia? The possible presence of a binding protein for PACAP38 in blood

Ann N Y Acad Sci. 1998 Dec 11:865:595-600. doi: 10.1111/j.1749-6632.1998.tb11243.x.
No abstract available

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Carrier Proteins / blood*
  • Cell Death / drug effects
  • Cells, Cultured
  • Cyclic AMP / metabolism
  • Drug Administration Schedule
  • Humans
  • Infusions, Intravenous
  • Injections, Intravenous
  • Ischemic Attack, Transient / pathology*
  • Ischemic Attack, Transient / physiopathology
  • Neurons / drug effects
  • Neurons / pathology*
  • Neuropeptides / administration & dosage
  • Neuropeptides / blood*
  • Neuropeptides / pharmacology*
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / blood
  • Neuroprotective Agents / pharmacology*
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Pituitary Gland / drug effects
  • Pituitary Gland / physiology
  • Posture
  • Prosencephalon / pathology
  • Prosencephalon / physiopathology
  • Rabbits
  • Rats

Substances

  • ADCYAP1 protein, human
  • Adcyap1 protein, rat
  • Carrier Proteins
  • Neuropeptides
  • Neuroprotective Agents
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Cyclic AMP
  • Adenylyl Cyclases