Abstract
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretagogues with low nanomolar in vitro activity.
MeSH terms
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Animals
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Growth Hormone / metabolism*
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In Vitro Techniques
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Indoles / chemistry
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Indoles / pharmacology
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Piperidines / chemistry*
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Piperidines / pharmacology
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Pituitary Gland / drug effects
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Pituitary Gland / metabolism
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Rats
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Spiro Compounds / chemistry*
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Indoles
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L 162752
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Piperidines
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Spiro Compounds
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Growth Hormone
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ibutamoren mesylate