The complete genomic sequence of an HTLV-II isolate from a Guahibo Indian from Venezuela

Virology. 1999 Jan 20;253(2):181-92. doi: 10.1006/viro.1998.9515.

Abstract

A polyclonal CD3(+), CD8(+) T-cell line, G2, was derived from the peripheral blood of a seropositive, PCR-positive, HTLV-IIB infected Guahibo Indian from Venezuela. The cell line is productively infected with HTLV-IIB. The entire HTLV-II G2 proviral DNA was sequenced via PCR using overlapping HTLV-II primer pairs. Phylogenetic analyses indicate that HTLV-II G2 is the most divergent HTLV-IIB strain identified to date. Characterization of its deduced proteins and its relationship to other members of the PTLV/BLV genus of retroviruses are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cells, Cultured
  • DNA, Viral / analysis
  • Genome, Viral*
  • Human T-lymphotropic virus 2 / classification
  • Human T-lymphotropic virus 2 / genetics*
  • Human T-lymphotropic virus 2 / isolation & purification
  • Humans
  • Immunophenotyping
  • Indians, South American*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Venezuela

Substances

  • DNA, Viral

Associated data

  • GENBANK/AF074965