Negative control elements of the cell cycle in human tumors

Curr Opin Cell Biol. 1998 Dec;10(6):791-7. doi: 10.1016/s0955-0674(98)80123-3.

Abstract

The retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or indirectly, inactivated in the majority of human tumors. Recent studies have provided new mechanistic insights into how these proteins regulate cell growth in response to various intracellular and extracellular signals.

Publication types

  • Review

MeSH terms

  • Cell Cycle / genetics
  • Cell Cycle / physiology*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism
  • Retinoblastoma Protein / physiology*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53