The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I

Mamm Genome. 1999 Jan;10(1):49-53. doi: 10.1007/s003359900941.

Abstract

The genomic organization of the human 51-kDa subunit gene (NDUFV1) on human Chromosome (Chr) 11q13 was determined. The NDUFV1 gene consists of 10 exons. Exon 1 encodes for the 20-amino-acids-long import sequence, and exon 1 through 10 codes for the 444-amino-acids-long mature protein. The protein sequence is highly conserved between human and bovine. Northern blotting analysis showed that the NDUFV1 gene expression varies widely among tissues and that in testis a unique mRNA species is present. In comparison with the other complex I flavoproteins, the expression of the 51-kDa gene in pancreatic tissue is high.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Cattle
  • Cloning, Molecular
  • Electron Transport Complex I
  • Exons
  • Gene Library
  • Humans
  • Introns
  • Molecular Sequence Data
  • NADH Dehydrogenase
  • Proteins / genetics*
  • Proteins / metabolism
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Tissue Distribution

Substances

  • NDUFV1 protein, human
  • Proteins
  • NADH Dehydrogenase
  • Electron Transport Complex I

Associated data

  • GENBANK/Y16310