Synthesis of 2-hydroxy acid from 2-amino acid by Clostridium butyricum

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3429-34. doi: 10.1016/s0960-894x(98)00620-9.

Abstract

Cultures of Clostridium butyricum type strain in synthetic medium supplemented with various L-2-amino acids revealed the presence of the corresponding 2-hydroxy acid. This metabolite is able to produce the polyester poly(2-hydroxyalkanoic acid). The bioconversion is not stereoselective since D-2-amino acids were also converted. Chiral GC analysis demonstrated that only D-enantiomer is formed from L-leucine.

MeSH terms

  • Amino Acids / metabolism*
  • Clostridium / metabolism*
  • Hydroxy Acids / metabolism*
  • Molecular Conformation

Substances

  • Amino Acids
  • Hydroxy Acids