A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3.

Abstract

The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Neuraminidase / antagonists & inhibitors*
  • Neuraminidase / chemistry
  • Orthomyxoviridae / drug effects*
  • Orthomyxoviridae / enzymology
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Aza Compounds
  • Enzyme Inhibitors
  • Neuraminidase