Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities

N I Carruthers; J M Spitler; S C Wong; D J Blythin; X Chen; H J Shue; H S She; J F Lee; C Rizzo; P C Ting; R E West Jr

doi:10.1016/S0960-894X(98)00565-4

Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities

Bioorg Med Chem Lett. 1998 Nov 3;8(21):3059-64. doi: 10.1016/S0960-894X(98)00565-4.

Authors

N I Carruthers¹, J M Spitler, S C Wong, D J Blythin, X Chen, H J Shue, H S She, J F Lee, C Rizzo, P C Ting, R E West Jr

Affiliation

¹ Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

PMID: 9873676
DOI: 10.1016/S0960-894X(98)00565-4

Abstract

A series of gamma-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABAB receptor investigated.

MeSH terms

Receptors, GABA-B / metabolism*
Structure-Activity Relationship
Sulfinic Acids / chemical synthesis*
Sulfinic Acids / metabolism
gamma-Aminobutyric Acid / chemical synthesis*
gamma-Aminobutyric Acid / metabolism

Substances

Receptors, GABA-B
Sulfinic Acids
gamma-Aminobutyric Acid