Naphthoquinone analogs as inactivators of cdc25 phosphatase

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2507-10. doi: 10.1016/s0960-894x(98)00411-9.

Abstract

cdc25A and cdc25B were significantly overexpressed in certain types of cancers, and they represent potential therapeutic targets for anticancer drug. In this study, naphthoquinone analogs as cdc25A phosphatase inactivators were investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Flow Cytometry
  • GTP-Binding Proteins / antagonists & inhibitors*
  • Humans
  • Models, Chemical
  • Naphthoquinones / chemistry*
  • Naphthoquinones / pharmacology
  • Phosphoprotein Phosphatases / antagonists & inhibitors*
  • Tumor Cells, Cultured
  • Vitamin K / chemistry
  • cdc25 Phosphatases

Substances

  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Naphthoquinones
  • Vitamin K
  • Phosphoprotein Phosphatases
  • cdc25 Phosphatases
  • GTP-Binding Proteins