Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins

T Tanami; K Kameo; N Ono; T Nakagawa; S Annou; M Tsuboi; K Tani; S Okamoto; F Sato

doi:10.1016/s0960-894x(98)00247-9

Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1507-10. doi: 10.1016/s0960-894x(98)00247-9.

Authors

T Tanami¹, K Kameo, N Ono, T Nakagawa, S Annou, M Tsuboi, K Tani, S Okamoto, F Sato

Affiliation

¹ Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

PMID: 9873379
DOI: 10.1016/s0960-894x(98)00247-9

Abstract

13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.

MeSH terms

Animals
Guinea Pigs
Humans
Ileum / drug effects
Ileum / physiology
Magnetic Resonance Spectroscopy
Molecular Structure
Muscle Contraction / drug effects
Platelet Aggregation Inhibitors / chemical synthesis
Platelet Aggregation Inhibitors / pharmacology
Prostaglandins / chemical synthesis*
Prostaglandins / chemistry
Prostaglandins / pharmacology*

Substances

Platelet Aggregation Inhibitors
Prostaglandins