Abstract
One, two-disubstituted carbocyclic nucleoside analogues bearing a 2-amino-6-substituted (chloro, hydroxy or amino) purine or 8-azapurine base were prepared by constructing the base about (+/-)-2-aminocyclopentane methanol, and their activities against a selection of viruses and tumor cells were determined in vitro.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Purine Nucleosides / chemical synthesis*
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Purine Nucleosides / pharmacology
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Tumor Cells, Cultured
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Viruses / drug effects
Substances
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Antineoplastic Agents
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Antiviral Agents
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Purine Nucleosides