Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology

Bioorg Med Chem Lett. 1998 Feb 3;8(3):267-72. doi: 10.1016/s0960-894x(98)00004-3.

Abstract

The synthesis of LIAZAL (compound 9, R085246) is described. LIAZAL inhibits all-trans-retinoic acid metabolism and thereby exerts retinoid-like effects in vivo.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System
  • Dermatologic Agents / chemical synthesis*
  • Dermatologic Agents / chemistry
  • Dermatologic Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Rats
  • Retinoic Acid 4-Hydroxylase
  • Tretinoin / antagonists & inhibitors*
  • Tretinoin / metabolism

Substances

  • Antineoplastic Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Dermatologic Agents
  • Enzyme Inhibitors
  • Imidazoles
  • Tretinoin
  • Cytochrome P-450 Enzyme System
  • Retinoic Acid 4-Hydroxylase
  • liarozole