Treatment of chronic viral hepatitis

Antivir Chem Chemother. 1998 Nov;9(6):449-60. doi: 10.1177/095632029800900601.

Abstract

Interferon-alpha therapy has proved effective for up to 40% of patients with adult-acquired chronic hepatitis B virus (HBV) infection and for 20-25% of those with chronic hepatitis C virus (HCV) infection. Nucleoside analogues, such as lamivudine and famciclovir, are showing promise as antiviral agents for chronic HBV and the combination of interferon-alpha and ribavirin is proving to be successful therapy for 40-50% of patients with chronic HCV. In this article we review current therapy and discuss future strategies of the therapy of chronic viral hepatitis.

Publication types

  • Review

MeSH terms

  • 2-Aminopurine / analogs & derivatives
  • 2-Aminopurine / therapeutic use
  • Animals
  • Antimetabolites / therapeutic use
  • Antiviral Agents / therapeutic use*
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / prevention & control
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Ducks
  • Famciclovir
  • Female
  • Hepatitis B, Chronic / drug therapy
  • Hepatitis B, Chronic / therapy*
  • Hepatitis C, Chronic / drug therapy
  • Hepatitis C, Chronic / therapy*
  • Hepatitis, Animal / virology
  • Humans
  • Immunologic Factors / therapeutic use*
  • Interferon-alpha / therapeutic use
  • Lamivudine / therapeutic use
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / prevention & control
  • Liver Neoplasms / etiology
  • Liver Neoplasms / pathology
  • Liver Neoplasms / prevention & control
  • Male
  • Marmota
  • Poultry Diseases / virology
  • Randomized Controlled Trials as Topic
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Tumor Cells, Cultured

Substances

  • Antimetabolites
  • Antiviral Agents
  • Immunologic Factors
  • Interferon-alpha
  • Reverse Transcriptase Inhibitors
  • Lamivudine
  • 2-Aminopurine
  • Famciclovir