Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues

J Med Chem. 1998 Dec 3;41(25):4915-7. doi: 10.1021/jm980421f.

Authors

R V Bonnert¹, R C Brown, D Chapman, D R Cheshire, J Dixon, F Ince, E C Kinchin, A J Lyons, A M Davis, C Hallam, S T Harper, J F Unitt, I G Dougall, D M Jackson, K McKechnie, A Young, W T Simpson

Affiliation

¹ Astra Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.

PMID: 9836607
DOI: 10.1021/jm980421f

No abstract available

MeSH terms

Adrenergic beta-2 Receptor Agonists*
Adrenergic beta-Agonists / chemical synthesis*
Adrenergic beta-Agonists / pharmacology
Animals
Anti-Asthmatic Agents / chemical synthesis*
Anti-Asthmatic Agents / pharmacology
Bronchoconstriction / drug effects
Dogs
Dopamine Agonists / chemical synthesis*
Dopamine Agonists / pharmacology
Drug Evaluation, Preclinical
Ear / blood supply
In Vitro Techniques
Lung Diseases, Obstructive / drug therapy*
Mucus / drug effects
Rabbits
Receptors, Dopamine D2 / agonists*
Respiration / drug effects
Thiazoles / chemical synthesis*
Thiazoles / pharmacology
Vasoconstriction / drug effects

Substances

Adrenergic beta-2 Receptor Agonists
Adrenergic beta-Agonists
Anti-Asthmatic Agents
Dopamine Agonists
Receptors, Dopamine D2
Thiazoles
sibenadet