D-penicillamine treatment for chronic sensory ataxic neuropathy associated with Sjögren's syndrome

Neurology. 1998 Nov;51(5):1451-3. doi: 10.1212/wnl.51.5.1451.

Abstract

Beneficial treatment has not been established for chronic sensory ataxic neuropathy associated with Sjögren's syndrome (CSAN-SS). We describe two patients with CSAN-SS who clinically improved in response to D-penicillamine treatment. Their neuropathic symptoms were lessened after D-penicillamine, and the results of electrophysiologic studies support the clinical improvement. D-Penicillamine can be considered a potentially beneficial agent in the treatment of CSAN-SS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antirheumatic Agents / therapeutic use*
  • Ataxia / drug therapy*
  • Ataxia / etiology
  • Evoked Potentials, Somatosensory
  • Female
  • Humans
  • Median Nerve / physiopathology
  • Neural Conduction / drug effects*
  • Neural Conduction / physiology
  • Neurologic Examination
  • Penicillamine / therapeutic use*
  • Sjogren's Syndrome / drug therapy*
  • Sjogren's Syndrome / physiopathology*
  • Sural Nerve / physiopathology
  • Ulnar Nerve / physiopathology

Substances

  • Antirheumatic Agents
  • Penicillamine