A 10-year-old ovariohysterectomised domestic shorthaired cat was presented with multiple nodular calcifications of the footpads and interdigital spaces. Renal insufficiency was diagnosed by routine biochemistry and urinalysis. Additionally, the cat had a calcium and phosphorus solubility product greater than 70 mg/dl and elevated circulating parathyroid hormone. Dietary management of the renal disease resulted in a reduction in the mineral solubility product and normalisation of the concentration of parathyroid hormone accompanied by concurrent resolution of the pedal lesions.