Abstract
Infection of human mononuclear cells with Marburg virus results in production of inflammatory cytokines tumor necrosis factor and interleukin-1. These cytokines induce expression of adhesion receptors VCAM and ICAM by human endothelial cells. Mitogen-induced proliferation of human mononuclears is not suppressed 1 h after infection of these cells with Marburg virus in a dose of 0.01 PFU/cell. The capacity of cells to proliferate in response to mitogens significantly decreased 4 h after infection.
MeSH terms
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Base Sequence
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Cell Division
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Cells, Cultured
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DNA Primers
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Endothelium, Vascular / cytology
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Endothelium, Vascular / metabolism
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Humans
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Intercellular Adhesion Molecule-1 / biosynthesis
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Interleukin-1 / biosynthesis*
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Interleukin-1 / metabolism
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Marburgvirus / immunology*
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Mitogens / metabolism
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Monocytes / immunology*
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Monocytes / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Serial Passage
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Tumor Necrosis Factor-alpha / biosynthesis*
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Tumor Necrosis Factor-alpha / metabolism
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Vascular Cell Adhesion Molecule-1 / biosynthesis
Substances
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DNA Primers
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Interleukin-1
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Mitogens
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Tumor Necrosis Factor-alpha
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Vascular Cell Adhesion Molecule-1
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Intercellular Adhesion Molecule-1