[Association of Biermer's anemia and gastric carcinoid tumors]

Rev Med Interne. 1998 Jan;19(1):51-4. doi: 10.1016/s0248-8663(97)83700-9.
[Article in French]

Abstract

Background: The occurrence of gastric carcinoid tumors during the cure of pernicious anemia has been reported in the literature. Concerning a new case, we review physiopathological data of this infrequent association.

Case report: We report the case of a 47-year-old women with pernicious anemia in which gastroscopy found two small tumors developed from enterochromaffin-like cells.

Conclusion: These tumors are usually latent and developed from enterochromaffin-like cells. The pathologic and histologic diagnosis is based on positive chromogranin A immunomarking. The physiopathological mechanism studies are in favour of the predominant part of hypergastrinemia following achlorhydria. Usually, evolution is benign and surgical or endoscopic resection recommended.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anemia, Pernicious / complications*
  • Anemia, Pernicious / drug therapy
  • Carcinoid Tumor / complications*
  • Carcinoid Tumor / diagnosis
  • Carcinoid Tumor / pathology
  • Chromogranin A
  • Chromogranins / analysis
  • Enterochromaffin-like Cells / pathology
  • Female
  • Follow-Up Studies
  • Gastroscopy
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / pathology
  • Time Factors
  • Vitamin B 12 / therapeutic use

Substances

  • Chromogranin A
  • Chromogranins
  • Vitamin B 12