Abstract
Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition: cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / antagonists & inhibitors*
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Adenosine / analogs & derivatives
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Adenosine / pharmacology
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Drug Design
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Drug Therapy*
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Enzyme Inhibitors / pharmacology*
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Glycine Hydroxymethyltransferase / antagonists & inhibitors*
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Humans
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Kinetics
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Molecular Structure
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Threonine / analogs & derivatives
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Threonine / metabolism
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Transcobalamins / metabolism
Substances
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Enzyme Inhibitors
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Transcobalamins
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Threonine
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Glycine Hydroxymethyltransferase
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Adenosine
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sinefungin