Increasing survival of very preterm and sick neonates has lead to more concern about development outcome. Risk factors include antenatal, perinatal and socioeconomic factors. Developmental assessment has to be repeated during infancy till late school age (at term 3, 6, 12, 18, 42 months corrected age ...). Neurological examination, sensorial assessment and cognitive evaluation with special attention to visuo-spatial factors are mandatory.